Buscar
Mostrando ítems 11-20 de 21
Artículo
Pathophysiological and molecular considerations of viral and bacterial infections during maternal-fetal and –neonatal interactions of SARS-CoV-2, Zika, and Mycoplasma infectious diseases
(Elsevier, 2021)
During pregnancy, a series of physiological changes are determined at the molecular, cellular and macroscopic level that make the mother and fetus more susceptible to certain viral and bacterial infections, especially the ...
Artículo
Impact of maternal nutrition in viral infections during pregnancy
(Elsevier, 2021)
Other than being a physiological process, pregnancy is a condition characterized by major adaptations of maternal endocrine and metabolic homeostasis that are necessary to accommodate the fetoplacental unit. Unfortunately, ...
Artículo
Exosomes derived from monocytes and from endothelial cells mediate monocyte and endothelial cell activation under high d-glucose conditions
(Elsevier, 2019)
Diabetes mellitus type 2 (DMT2) is characterized by hyperglycemia and associated with low grade inflammation affecting both endothelial cells and monocytes. Exosomes are nanovesicles, allow communication between endothelial ...
Artículo
Reduced L-carnitine transport in aortic endothelial cells from spontaneously hypertensive rats
(Public Library of Science, 2014)
Impaired L-carnitine uptake correlates with higher blood pressure in adult men, and L-carnitine restores endothelial function in aortic rings from spontaneously hypertensive rat (SHR). Thus, endothelial dysfunction in ...
Artículo
Intracellular acidification reduces L-arginine transport via system y + L but not via system y + /CATs and nitric oxide synthase activity in human umbilical vein endothelial cells
(Elsevier, 2018)
L-Arginine is taken up via the cationic amino acid transporters (system y + /CATs) and system y + L in human umbilical vein endothelial cells (HUVECs). L-Arginine is the substrate for endothelial NO synthase (eNOS) which ...
Artículo
Escherichia coli heat-stable enterotoxin mediates Na+/H+ exchanger 4 inhibition involving cAMP in T84 human intestinal epithelial cells
(Public Library of Science, 2015)
The enterotoxigenic Escherichia coli strains lead to diarrhoea in humans due to heat-labile and heat-stable (STa) enterotoxins. STa increases Cl-release in intestinal cells, including the human colonic carcinoma T84 cell ...
Artículo
Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta
(Hindawi Publishing Corporation, 2016)
The vascular endothelium plays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a ...
Artículo
Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy
(Hindawi Publishing Corporation, 2017)
Insulin resistance is characteristic of pregnancies where the mother shows metabolic alterations, such as preeclampsia (PE) and gestational diabetes mellitus (GDM), or abnormal maternal conditions such as pregestational ...
Artículo
Oxidative stress: Normal pregnancy versus preeclampsia
(Elsevier, 2020)
The role of oxidative stress in the physiopathology of human pregnancy is of particular interest. Pregnancy is well-known to increase the oxidative stress, mainly produced by a normal systemic inflammatory response, which ...
Artículo
Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer
(Elsevier, 2017)
Cancer cells generate protons (H+) that are extruded to the extracellular medium mainly via the Na+/H+ exchanger 1 (NHE1), which regulates intracellular pH (pHi) and cell proliferation. In primary cultures of human ...