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Mostrando ítems 1-10 de 35
Artículo
Functional Diversity of Neurotrophin Actions on the Oculomotor System
(MDPI AG, 2016)
Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance of appropriate adult neuronal circuits and phenotypes. In the oculomotor system, we have demonstrated ...
Artículo
The Use of PRV-Bartha to Define Premotor Inputs to Lumbar Motoneurons in the Neonatal Spinal Cord of the Mouse
(Public Library of Science, 2010)
Background The neonatal mouse has become a model system for studying the locomotor function of the lumbar spinal cord. However, information about the synaptic connectivity within the governing neural network remains ...
Artículo
Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles
(MDPI, 2020)
Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that they are endowed with different types of myogenic cells, all of which present an outstanding regenerative ...
Tesis Doctoral
Dependencias tróficas y sinápticas del sistema oculomotor.
(2018-02-23)
Las motoneuronas del recto medial presentes en el núcleo motor ocular común (NMOC) reciben dos entradas pontinas principales: las neuronas internucleares del núcleo motor ocular externo (NMOE), cuyos axones discurren por ...
Tesis Doctoral
Implante de progenitores neurales en un modelo de lesión del sistema oculomotor
(2015-11-11)
El implante de células progenitoras neurales en el sistema nervioso central lesionado es una poderosa herramienta reparadora. Sin embargo, aún no se han evaluado extensamente los efectos de dichos implantes sobre el patrón ...
Artículo
Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat
(Frontiers Media, 2018)
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, there is growing evidence indicating that VEGF also acts as a neuroprotective factor, and that its ...
Artículo
Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment
(MDPI, 2019)
The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with the tumor microenvironment in order to tune it for their own benefit. Among these, extracellular ...
Artículo
Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells
(Frontiers Research Foundation, 2015)
The postnatal subventricular zone (SVZ) lining the walls of the lateral ventricles contains neural progenitor cells (NPCs) that generate new olfactory bulb interneurons. Communication via gap junctions between cells in the ...
Artículo
A Single Intraventricular Injection of VEGF Leads to Long-Term Neurotrophic Effects in Axotomized Motoneurons
(Society for Neuroscience, 2020)
Vascular endothelial growth factor (VEGF) has been recently demonstrated to induce neuroprotective and synaptotrophic effects on lesioned neurons. Hitherto, the administration of VEGF in different animal models of lesion ...
Artículo
Nerve Growth Factor Regulates the Firing Patterns and Synaptic Composition of Motoneurons
(Society for Neuroscience, 2010)
Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involved in the regulation of different forms of synaptic plasticity. Target disconnection produces a profound synaptic stripping ...