Now showing items 1-10 of 15
Maternal supraphysiological hypercholesterolemia associates with endothelial dysfunction of the placental microvasculature [Article]
(Nature Publishing Group, 2018)
Maternal physiological or supraphysiological hypercholesterolemia (MPH, MSPH) occurs during pregnancy. MSPH is associated with foetal endothelial dysfunction and atherosclerosis. However, the potential effects of MSPH on ...
Escherichia coli heat-stable enterotoxin mediates Na+/H+ exchanger 4 inhibition involving cAMP in T84 human intestinal epithelial cells [Article]
(Public Library of Science, 2015)
The enterotoxigenic Escherichia coli strains lead to diarrhoea in humans due to heat-labile and heat-stable (STa) enterotoxins. STa increases Cl-release in intestinal cells, including the human colonic carcinoma T84 cell ...
Reduced L-carnitine transport in aortic endothelial cells from spontaneously hypertensive rats [Article]
(Public Library of Science, 2014)
Impaired L-carnitine uptake correlates with higher blood pressure in adult men, and L-carnitine restores endothelial function in aortic rings from spontaneously hypertensive rat (SHR). Thus, endothelial dysfunction in ...
Nitric Oxide: A Regulator of Cellular Function in Health and Disease [Article]
(Hindawi Publishing Corporation, 2016)
Insulin Reverses D-Glucose–Increased Nitric Oxide and Reactive Oxygen Species Generation in Human Umbilical Vein Endothelial Cells [Article]
(Public Library of Science, 2015)
Vascular tone is controlled by the L-arginine/nitric oxide (NO) pathway, and NO bioavailability is strongly affected by hyperglycaemia-induced oxidative stress. Insulin leads to high expression and activity of human cationic ...
Akt/mTOR Role in Human Foetoplacental Vascular Insulin Resistance in Diseases of Pregnancy [Article]
(Hindawi Publishing Corporation, 2017)
Insulin resistance is characteristic of pregnancies where the mother shows metabolic alterations, such as preeclampsia (PE) and gestational diabetes mellitus (GDM), or abnormal maternal conditions such as pregestational ...
Fetoplacental endothelial exosomes modulate high d-glucose-induced endothelial dysfunction [Article]
Gestational diabetes mellitus (GDM) is associated with fetoplacental endothelial dysfunction, which may be induced by hyperglycemia. We hypothesized that endothelial exosomes, which are extracellular nanovesicles affecting ...
Exosomes derived from monocytes and from endothelial cells mediate monocyte and endothelial cell activation under high d-glucose conditions [Article]
Diabetes mellitus type 2 (DMT2) is characterized by hyperglycemia and associated with low grade inflammation affecting both endothelial cells and monocytes. Exosomes are nanovesicles, allow communication between endothelial ...
La regulación del transporte de L-arginina vía HCAT-1 por insulina involucra activación diferencial de los subtipos A y B de receptores de insulina y receptores de adenosina en células endoteliales de vena umbilical humana de diabetes gestacional [PhD Thesis]
Diabetes gestacional (DG) aumenta el transporte de L-arginina en la macrocirculación de la placenta. Insulina activa receptores de insulina (IRs) los cuales estimulan el transporte de Larginina via transportadores de ...
Cross Talk between Adipose Tissue and Placenta in Obese and Gestational Diabetes Mellitus Pregnancies via Exosomes [Article]
(Frontiers Media, 2017)
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk ...