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Artículo
Intracellular acidification reduces L-arginine transport via system y + L but not via system y + /CATs and nitric oxide synthase activity in human umbilical vein endothelial cells
(Elsevier, 2018)
L-Arginine is taken up via the cationic amino acid transporters (system y + /CATs) and system y + L in human umbilical vein endothelial cells (HUVECs). L-Arginine is the substrate for endothelial NO synthase (eNOS) which ...
Artículo
Escherichia coli heat-stable enterotoxin mediates Na+/H+ exchanger 4 inhibition involving cAMP in T84 human intestinal epithelial cells
(Public Library of Science, 2015)
The enterotoxigenic Escherichia coli strains lead to diarrhoea in humans due to heat-labile and heat-stable (STa) enterotoxins. STa increases Cl-release in intestinal cells, including the human colonic carcinoma T84 cell ...
Artículo
Sodium/proton exchanger isoform 1 regulates intracellular pH and cell proliferation in human ovarian cancer
(Elsevier, 2017)
Cancer cells generate protons (H+) that are extruded to the extracellular medium mainly via the Na+/H+ exchanger 1 (NHE1), which regulates intracellular pH (pHi) and cell proliferation. In primary cultures of human ...