dc.creator | Silva Hucha, Silvia | es |
dc.creator | Pastor Loro, Ángel Manuel | es |
dc.creator | Morcuende Fernández, Sara R. | es |
dc.date.accessioned | 2021-02-22T12:15:55Z | |
dc.date.available | 2021-02-22T12:15:55Z | |
dc.date.issued | 2021-01 | |
dc.identifier.citation | Silva Hucha, S., Pastor Loro, Á.M. y Morcuende Fernández, S.R. (2021). Neuroprotective Effect of Vascular Endothelial Growth Factor on Motoneurons of the Oculomotor System. International Journal of Molecular Sciences, 22 (2), 814. | |
dc.identifier.issn | 1422-0067 | es |
dc.identifier.issn | 1661-6596 | es |
dc.identifier.uri | https://hdl.handle.net/11441/105242 | |
dc.description.abstract | Vascular endothelial growth factor (VEGF) was initially characterized as a potent angiogenic factor based on its activity on the vascular system. However, it is now well established
that VEGF also plays a crucial role as a neuroprotective factor in the nervous system. A deficit
of VEGF has been related to motoneuronal degeneration, such as that occurring in amyotrophic
lateral sclerosis (ALS). Strikingly, motoneurons of the oculomotor system show lesser vulnerability to
neurodegeneration in ALS compared to other motoneurons. These motoneurons presented higher
amounts of VEGF and its receptor Flk-1 than other brainstem pools. That higher VEGF level could
be due to an enhanced retrograde input from their target muscles, but it can also be produced by
the motoneurons themselves and act in an autocrine way. By contrast, VEGF’s paracrine supply
from the vicinity cells, such as glial cells, seems to represent a minor source of VEGF for brainstem
motoneurons. In addition, ocular motoneurons experiment an increase in VEGF and Flk-1 level in
response to axotomy, not observed in facial or hypoglossal motoneurons. Therefore, in this review,
we summarize the differences in VEGF availability that could contribute to the higher resistance of
extraocular motoneurons to injury and neurodegenerative diseases. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación de España (MCI), Agencia Estatal de Investigación de España (AEI) y Fondo Europeo de Desarrollo Regional (FEDER)-BFU2015-64515-P y PGC2018-094654-B-100 | es |
dc.description.sponsorship | Junta de Andalucía-BIO-297 | |
dc.format | application/pdf | es |
dc.format.extent | 20 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | International Journal of Molecular Sciences, 22 (2), 814. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | VEGF | es |
dc.subject | oculomotor system | es |
dc.subject | trophic factors | es |
dc.subject | motoneurons | es |
dc.subject | neurodegeneration | es |
dc.subject | axotomy | es |
dc.subject | amyotrophic lateral sclerosis | es |
dc.title | Neuroprotective Effect of Vascular Endothelial Growth Factor on Motoneurons of the Oculomotor System | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.projectID | BFU2015-64515-P | es |
dc.relation.projectID | PGC2018-094654-B-100 | es |
dc.relation.projectID | BIO-297 | |
dc.relation.publisherversion | https://doi.org/10.3390/ijms22020814 | es |
dc.identifier.doi | 10.3390/ijms22020814 | es |
dc.contributor.group | Universidad de Sevilla. BIO297: Laboratorio de Fisiología y Plasticidad Neuronal | es |
dc.journaltitle | International Journal of Molecular Sciences | es |
dc.publication.volumen | 22 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 814 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Junta de Andalucía | |