dc.creator | Marinho, Sonia | es |
dc.creator | Illanes, Matilde | es |
dc.creator | Ávila Román, Francisco Javier | es |
dc.creator | Motilva, Virginia | es |
dc.creator | Talero, Elena | es |
dc.date.accessioned | 2021-02-05T12:12:44Z | |
dc.date.available | 2021-02-05T12:12:44Z | |
dc.date.issued | 2021-01-26 | |
dc.identifier.citation | Marinho, S., Illanes, M., Ávila Román, J., Motilva, V. y Talero, E. (2021). Anti-inflammatory effects of rosmarinic acid-loaded nanovesicles in acute colitis through modulation of NLRP3 inflammasome. Biomolecules, 11 (2), 1-17. | |
dc.identifier.issn | 2218-273X | es |
dc.identifier.uri | https://hdl.handle.net/11441/104665 | |
dc.description.abstract | Ulcerative colitis (UC), one of the two main types of inflammatory bowel disease, has
no effective treatment. Rosmarinic acid (RA) is a polyphenol that, when administered orally, is
metabolised in the small intestine, compromising its beneficial effects. We used chitosan/nutriosecoated
niosomes loaded with RA to protect RA from gastric degradation and target the colon and
evaluated their effect on acute colitis induced by 4% dextran sodium sulphate (DSS) for seven days in
mice. RA-loaded nanovesicles (5, 10 and 20 mg/kg) or free RA (20 mg/kg) were orally administered
from three days prior to colitis induction and during days 1, 3, 5 and 7 of DSS administration.
RA-loaded nanovesicles improved body weight loss and disease activity index as well as increased
mucus production and decreased myeloperoxidase activity and TNF-_ production. Moreover,
RA-loaded nanovesicles downregulated protein expression of inflammasome components such
as NLR family pyrin domain-containing 3 (NLRP3), adaptor protein (ASC) and caspase-1, and
the consequent reduction of IL-1_ levels. Furthermore, nuclear factor erythroid 2-related factor
2 (Nrf2) and heme oxygenase-1 (HO-1) protein expression increased after the RA-loaded nanovesicles
treatment However, these mechanistic changes were not detected with the RA-free treatment. Our
findings suggest that the use of chitosan/nutriose-coated niosomes to increase RA local bioavailability
could be a promising nutraceutical strategy for oral colon-targeted UC therapy. | es |
dc.description.sponsorship | Consejería de Innovación, Ciencia y Empresa-Junta de Andalucía, subvención número P12-AGR-430 (POLFANAT) | es |
dc.format | application/pdf | es |
dc.format.extent | 17 | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Biomolecules, 11 (2), 1-17. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Ulcerative colitis | es |
dc.subject | Rosmarinic acid | es |
dc.subject | Nanovesicles | es |
dc.subject | Inflammasome | es |
dc.subject | Nrf2 | es |
dc.title | Anti-inflammatory effects of rosmarinic acid-loaded nanovesicles in acute colitis through modulation of NLRP3 inflammasome | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología | es |
dc.relation.publisherversion | https://doi.org/10.3390/biom11020162 | es |
dc.identifier.doi | 10.3390/biom11020162 | es |
dc.journaltitle | Biomolecules | es |
dc.publication.volumen | 11 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 17 | es |