dc.creator | Santana Garrido, Álvaro | es |
dc.creator | Reyes Goya, Claudia | es |
dc.creator | Pérez-Camino, María del Carmen | es |
dc.creator | André, Helder | es |
dc.creator | Mate Barrero, Alfonso | es |
dc.creator | Vázquez Cueto, Carmen María | es |
dc.date.accessioned | 2020-12-03T13:06:48Z | |
dc.date.available | 2020-12-03T13:06:48Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Santana Garrido, Á., Reyes Goya, C., Pérez-Camino, M.d.C., André, H., Mate Barrero, A. y Vázquez Cueto, C.M. (2020). Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension. Antioxidants, 9, 1-32. | |
dc.identifier.issn | 2076-3921 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/102953 | |
dc.description.abstract | Oxidative stress plays an important role in the pathogenesis of ocular diseases,
including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases
might rely on minor constituents. Currently, very little is known about the chemical composition
and/or therapeutic effects of the cultivated olive tree’s counterpart, wild olive (also known
in Spain as acebuche—ACE). Here, we aimed to analyze the antioxidant and retinoprotective
effects of ACE oil on the eye of hypertensive mice made hypertensive via administration of
NG-nitro-L-arginine-methyl-ester (L-NAME), which were subjected to a dietary supplementation
with either ACE oil or extra virgin olive oil (EVOO) for comparison purposes. Deep analyses of
major and minor compounds present in both oils was accompanied by blood pressure monitoring,
morphometric analyses, as well as different determinations of oxidative stress-related parameters
in retinal layers. Aside from its antihypertensive effect, an ACE oil-enriched diet reduced NADPH
(nicotinamide adenine dinucleotide phosphate) oxidase activity/gene/protein expression (with a major
implication of NADPH oxidase (NOX)2 isoform) in the retinas of hypertensive mice. Supplementation
with ACE oil in hypertensive animals also improved alterations in nitric oxide bioavailability and in
antioxidant enzyme profile. Interestingly, our findings show that the use of ACE oil resulted in better
outcomes, compared with reference EVOO, against hypertension-related oxidative retinal damage. | es |
dc.description.sponsorship | Consejería de Economía, Conocimiento, Empresas y Universidad, Junta de Andalucía (2017/440; 2020/275; CTS-584) | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación, Gobierno de España (Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 | es |
dc.description.sponsorship | Programa Estatal de I+D+I PID2019-109002RB-I00 | es |
dc.format | application/pdf | es |
dc.format.extent | 32 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Antioxidants, 9, 1-32. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Acebuche | es |
dc.subject | Arterial hypertension | es |
dc.subject | NADPH (nicotinamide adenine dinucleotide phosphate) oxidase | es |
dc.subject | Nitric oxide | es |
dc.subject | Oxidative stress | es |
dc.subject | Retina | es |
dc.subject | Wild olive oil | es |
dc.title | Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología | es |
dc.relation.projectID | 2017/440 | es |
dc.relation.projectID | 2020/275 | es |
dc.relation.projectID | CTS-584 | es |
dc.relation.projectID | PID2019-109002RB-I00 | es |
dc.relation.publisherversion | https://doi.org/10.3390/antiox9090885 | es |
dc.identifier.doi | 10.3390/antiox9090885 | es |
dc.journaltitle | Antioxidants | es |
dc.publication.volumen | 9 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 32 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Consejería de Economía, conocimiento, Empresas y Universidad, Junta de Andalucía | es |