dc.creator | Balcerzyk, Marcin | es |
dc.creator | Miguel Rodríguez, Manuel de | es |
dc.creator | Guerrero Sánchez, Carlos | es |
dc.creator | Fernández Martínez, Begoña | es |
dc.date.accessioned | 2020-11-26T19:19:19Z | |
dc.date.available | 2020-11-26T19:19:19Z | |
dc.date.issued | 2020-09-12 | |
dc.identifier.citation | Balcerzyk, M., De-Miguel, M., Guerrero Sánchez, C. y Fernández Martínez, B. (2020). Quantification of Boron Compound Concentration for BNCT Using Positron Emission Tomography. Cells, 9 (9) | |
dc.identifier.issn | 2073-4409 | es |
dc.identifier.uri | https://hdl.handle.net/11441/102758 | |
dc.description.abstract | Boron neutron capture therapy requires a 2 mM 10B concentration in the
tumor. The well-known BNCT patient treatment method using boronophenylalanine (BPA) as a
boron-carrying agent utilizes [18F]fluoroBPA ([18F]FBPA) as an agent to qualify for treatment. Precisely,
[
18F]FBPA must have at least a 3:1 tumor to background tissue ratio to qualify the patient for BNCT
treatment. Normal, hyperplasia, and cancer thyroids capture iodine and several other large ions,
including BF4
−, through a sodium-iodine symporter (NIS) expressed on the cell surface in normal
conditions. In cancer, NIS is also expressed within the thyroid cell and is not functional. Methods:
To visualize the thyroids and NIS, we have used a [18F]NaBF4 positron emission tomography (PET)
tracer. It was injected into the tail veins of rats. The [18F]NaBF4 PET tracer was produced from NaBF4
by the isotopic exchange of natural 19F with radioactive 18F. Rats were subject to hyperplasia and
tumor-inducing treatment. The NIS in thyroids was visualized by immunofluorescence staining.
The boron concentration was calculated from Standard Uptake Values (SUV) in the PET/CT images
and from the production data. Results: 41 MBq, 0.64 pmol of [18F]NaBF4 PET tracer that contained
0.351 mM, 53 nmol of NaBF4 was injected into the tail vein. After 17 min, the peak activity in the
thyroid reached 2.3 MBq/mL (9 SUVmax). The natB concentration in the thyroid with hyperplasia
reached 381 nM. Conclusions: Such an incorporation would require an additional 110 mg/kg dose of
[
10B]NaBF4 to reach the necessary 2 mM 10B concentration in the tumor. For future BNCT treatments of
thyroid cancer, contrary to the 131I used now, there is no post-treatment radioactive decay, the patient
can be immediately discharged from hospital, and there is no six-month moratorium for pregnancy.
This method can be used for BNCT treatment compounds of the type R-BFn, where 1 <= n <= 3,
labeled with 18F relatively easily, as in our example. A patient may undergo injection of a mixture
of nonradioactive R-BFn to reach the necessary 10B concentration for BNCT treatment in the tumor
together, with [18F]R-BFn for boron mapping. | es |
dc.description.sponsorship | Spanish RTI2018-098117-B-C21 project | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Cells | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Boron neutron capture therapy | es |
dc.subject | Positron emission tomography | es |
dc.subject | Thyroid | es |
dc.subject | Sodium-iodine symporter | es |
dc.title | Quantification of Boron Compound Concentration for BNCT Using Positron Emission Tomography | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Citología e Histología Normal y Patológica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear | |
dc.relation.projectID | RTI2018-098117-B-C21 | es |
dc.relation.publisherversion | https://doi.org/10.3390/cells9092084 | es |
dc.identifier.doi | 10.3390/cells9092084 | es |
dc.journaltitle | Cells | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 9 | es |