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dc.creatorBalcerzyk, Marcines
dc.creatorMiguel Rodríguez, Manuel dees
dc.creatorGuerrero Sánchez, Carloses
dc.creatorFernández Martínez, Begoñaes
dc.identifier.citationBalcerzyk, M., De-Miguel, M., Guerrero Sánchez, C. y Fernández Martínez, B. (2020). Quantification of Boron Compound Concentration for BNCT Using Positron Emission Tomography. Cells, 9 (9)
dc.description.abstractBoron neutron capture therapy requires a 2 mM 10B concentration in the tumor. The well-known BNCT patient treatment method using boronophenylalanine (BPA) as a boron-carrying agent utilizes [18F]fluoroBPA ([18F]FBPA) as an agent to qualify for treatment. Precisely, [ 18F]FBPA must have at least a 3:1 tumor to background tissue ratio to qualify the patient for BNCT treatment. Normal, hyperplasia, and cancer thyroids capture iodine and several other large ions, including BF4 −, through a sodium-iodine symporter (NIS) expressed on the cell surface in normal conditions. In cancer, NIS is also expressed within the thyroid cell and is not functional. Methods: To visualize the thyroids and NIS, we have used a [18F]NaBF4 positron emission tomography (PET) tracer. It was injected into the tail veins of rats. The [18F]NaBF4 PET tracer was produced from NaBF4 by the isotopic exchange of natural 19F with radioactive 18F. Rats were subject to hyperplasia and tumor-inducing treatment. The NIS in thyroids was visualized by immunofluorescence staining. The boron concentration was calculated from Standard Uptake Values (SUV) in the PET/CT images and from the production data. Results: 41 MBq, 0.64 pmol of [18F]NaBF4 PET tracer that contained 0.351 mM, 53 nmol of NaBF4 was injected into the tail vein. After 17 min, the peak activity in the thyroid reached 2.3 MBq/mL (9 SUVmax). The natB concentration in the thyroid with hyperplasia reached 381 nM. Conclusions: Such an incorporation would require an additional 110 mg/kg dose of [ 10B]NaBF4 to reach the necessary 2 mM 10B concentration in the tumor. For future BNCT treatments of thyroid cancer, contrary to the 131I used now, there is no post-treatment radioactive decay, the patient can be immediately discharged from hospital, and there is no six-month moratorium for pregnancy. This method can be used for BNCT treatment compounds of the type R-BFn, where 1 <= n <= 3, labeled with 18F relatively easily, as in our example. A patient may undergo injection of a mixture of nonradioactive R-BFn to reach the necessary 10B concentration for BNCT treatment in the tumor together, with [18F]R-BFn for boron
dc.description.sponsorshipSpanish RTI2018-098117-B-C21 projectes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.subjectBoron neutron capture therapyes
dc.subjectPositron emission tomographyes
dc.subjectSodium-iodine symporteres
dc.titleQuantification of Boron Compound Concentration for BNCT Using Positron Emission Tomographyes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Citología e Histología Normal y Patológicaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Fisiología Médica y Biofísicaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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