dc.creator | Ciraldo, F. E. | es |
dc.creator | Arango-Ospina, M. | es |
dc.creator | Goldmann, W. H. | es |
dc.creator | Beltrán, Ana M. | es |
dc.creator | Detsch, R. | es |
dc.creator | Gruenewald, A. | es |
dc.creator | Roether, J. A. | es |
dc.creator | Boccaccini, Aldo R. | es |
dc.date.accessioned | 2020-10-23T12:31:09Z | |
dc.date.available | 2020-10-23T12:31:09Z | |
dc.date.issued | 2020-10 | |
dc.identifier.citation | Ciraldo, F.E., Arango-Ospina, M., Goldmann, W.H., Beltrán, A.M., Detsch, R., Gruenewald, A.,...,Boccaccini, A.R. (2020). Fabrication and characterization of Ag- and Ga-doped mesoporous glass-coated scaffolds based on natural marine sponges with improved mechanical properties. Journal of Biomedical Materials Research Part A, Octubre | |
dc.identifier.issn | 1552-4965 | es |
dc.identifier.uri | https://hdl.handle.net/11441/102194 | |
dc.description.abstract | Natural marine sponges were used as sacrificial template for the fabrication of bioactive glassbased scaffolds. After sintering at 1050 ºC, the resulting samples were additionally coated with a
sol silicate solution containing biologically active ions (Ag and Ga), well-known for their
antibacterial properties in comparison with standard scaffolds made by PU foam templates. The
produced scaffolds were characterized by superior mechanical properties (maximum compressive
strength of 4 MPa) and total porosity of ~80%. Direct cell culture tests performed on the
uncoated and coated samples showed positive results in terms of adhesion, proliferation, and
differentiation of MC3T3-E1 cells. Moreover, vascular endothelial growth factor (VEGF)
secretion from cells in contact with scaffold dissolution products was measured after 7 and 10
days of incubation, showing promising angiogenic results for bone tissue engineering
applications. The antibacterial potential of the produced samples was assessed by performing
agar diffusion tests against both Gram-positive and Gram-negative bacteria. | es |
dc.description.sponsorship | EU Horizon 2020 project COACH 642557 | es |
dc.format | application/pdf | es |
dc.format.extent | 53 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley Periodicals | es |
dc.relation.ispartof | Journal of Biomedical Materials Research Part A, Octubre | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Bioactive glass | es |
dc.subject | Bone tissue engineering | es |
dc.subject | Scaffolds | es |
dc.subject | Ion delivery | es |
dc.subject | VEGF | es |
dc.subject | Antibacterial | es |
dc.title | Fabrication and characterization of Ag- and Ga-doped mesoporous glass-coated scaffolds based on natural marine sponges with improved mechanical properties | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/embargoedAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte | es |
dc.relation.projectID | project COACH (ITNETN, Grant agreement 642557) | es |
dc.date.embargoEndDate | 2021-11 | |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.37123 | es |
dc.identifier.doi | 10.1002/jbm.a.37123 | es |
dc.contributor.group | Universidad de Sevilla. TEP123: Metalurgia e Ingeniería de los Materiales | es |
idus.validador.nota | Postprint. Peer Reviewed | es |
dc.journaltitle | Journal of Biomedical Materials Research Part A | es |
dc.publication.volumen | Octubre | es |