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dc.creatorPérez Pérez, Antonioes
dc.creatorSánchez Jiménez, Floraes
dc.creatorVilariño García, Teresaes
dc.creatorSánchez Margalet, Víctores
dc.date.accessioned2020-09-30T13:55:20Z
dc.date.available2020-09-30T13:55:20Z
dc.date.issued2020-08-16
dc.identifier.citationPérez Pérez, A., Sánchez Jiménez, F., Vilariño García, T. y Sánchez Margalet, V. (2020). Role of leptin in inflammation and vice versa. International Journal of Molecular Sciences, 21 (5887), 1-24. https://doi.org/doi:10.3390/ijms21165887.
dc.identifier.issn1422-0067es
dc.identifier.urihttps://hdl.handle.net/11441/101616
dc.description.abstractInflammation is an essential immune response for the maintenance of tissue homeostasis. In a general sense, acute and chronic inflammation are different types of adaptive response that are called into action when other homeostatic mechanisms are insufficient. Although considerable progress has been made in understanding the cellular and molecular events that are involved in the acute inflammatory response to infection and tissue injury, the causes and mechanisms of systemic chronic inflammation are much less known. The pathogenic capacity of this type of inflammation is puzzling and represents a common link of the multifactorial diseases, such as cardiovascular diseases and type 2 diabetes. In recent years, interest has been raised by the discovery of novel mediators of inflammation, such as microRNAs and adipokines, with different effects on target tissues. In the present review, we discuss the data emerged from research of leptin in obesity as an inflammatory mediator sustaining multifactorial diseases and how this knowledge could be instrumental in the design of leptin-based manipulation strategies to help restoration of abnormal immune responses. On the other direction, chronic inflammation, either from autoimmune or infectious diseases, or impaired microbiota (dysbiosis) may impair the leptin response inducing resistance to the weight control, and therefore it may be a cause of obesity. Thus, we are reviewing the published data regarding the role of leptin in inflammation, and the other way around, the role of inflammation on the development of leptin resistance and obesity.es
dc.formatapplication/pdfes
dc.format.extent24 p.es
dc.language.isoenges
dc.relation.ispartofInternational Journal of Molecular Sciences, 21 (5887), 1-24.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLeptines
dc.subjectInflammationes
dc.subjectObesityes
dc.subjectLeptin resistancees
dc.subjectMicrobiotaes
dc.titleRole of leptin in inflammation and vice versaes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Bioquímica Médica y Biofísica Molecular e Inmunologíaes
dc.identifier.doidoi:10.3390/ijms21165887es
dc.journaltitleInternational Journal of Molecular Scienceses
dc.publication.volumen21es
dc.publication.issue5887es
dc.publication.initialPage1es
dc.publication.endPage24es
dc.description.awardwinningPremio Mensual Publicación Científica Destacada de la US. Facultad de Medicina

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