dc.creator | Calvo Gutiérrez, Juan Ramón | es |
dc.creator | Maldonado y Aibar, María Dolores | es |
dc.date.accessioned | 2020-09-24T18:16:43Z | |
dc.date.available | 2020-09-24T18:16:43Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Calvo Gutiérrez, J.R. y Maldonado Aibar, M.D. (2016). The role of melatonin in autoimmune and atopic diseases. Aims Molecular Science, 3 (2), 158-186. | |
dc.identifier.issn | 2372-0301 | es |
dc.identifier.uri | https://hdl.handle.net/11441/101463 | |
dc.description.abstract | Melatonin is the main secretory product synthesized and secreted by the pineal gland during
the night. Melatonin is a pleitropic molecule with a wide distribution within phylogenetically distant
organisms and has a great functional versatility, including the regulation of circadian and seasonal
rhythms and antioxidant and anti-inflammatory properties. It also possesses the capacity to modulate
immune responses by regulation of the TH1/TH2 balance and cytokine production. Immune system
eradicates infecting organisms without serious injury to host tissues, but sometimes these responses
are inadequately controlled, giving rise to called hypersensitivity diseases, or inappropriately targeted
to host tissues, causing the autoimmune diseases. In clinical medicine, the hypersensitivity diseases
include the allergic or atopic diseases and the hallmarks of these diseases are the activation of TH2
cells and the production of IgE antibody. Regarding autoimmunity, at the present time we know that
the key events in the development of autoimmunity are a failure or breakdown of the mechanisms
normally responsible for maintaining self-tolerance in B lymphocytes, T lymphocytes, or both, the
recognition of self-antigens by autoreactive lymphocytes, the activation of these cells to proliferate
and differentiate into effector cells, and the tissue injury caused by the effector cells and their products.
Melatonin treatment has been investigated in atopic diseases, in several animal models of autoimmune
diseases, and has been also evaluated in clinical autoimmune diseases. This review summarizes the
role of melatonin in atopic diseases (atopic dermatitis and asthma) and in several autoimmune diseases,
such as arthritis rheumatoid, multiple sclerosis, systemic lupus erythematosus, type 1 diabetes mellitus,
and inflammatory bowel diseases. | es |
dc.description.sponsorship | Consejería de Innovación Ciencia y Empresa CTS-160 | es |
dc.format | application/pdf | es |
dc.format.extent | 29 | es |
dc.language.iso | eng | es |
dc.publisher | AIMS Press | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Melatonin | es |
dc.subject | Autoimmunity | es |
dc.subject | Atopic diseases | es |
dc.title | The role of melatonin in autoimmune and atopic diseases | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Médica y Biología Molecular e Inmunología | es |
dc.relation.projectID | CTS-160 | es |
dc.identifier.doi | 10.3934/molsci.2016.2.158 | es |
dc.journaltitle | Aims Molecular Science | es |
dc.publication.volumen | 3 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 158 | es |
dc.publication.endPage | 186 | es |