dc.creator | Humbert, Magali | es |
dc.creator | Morán, María | es |
dc.creator | Cruz Ojeda, Patricia de la | es |
dc.creator | Muntané Relat, Jordi | es |
dc.creator | Wiedmer, Tabea | es |
dc.creator | Apostolova, Nadezda | es |
dc.creator | Tschan, Mario P. | es |
dc.date.accessioned | 2020-08-26T17:32:57Z | |
dc.date.available | 2020-08-26T17:32:57Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Humbert, M., Morán, M., Cruz Ojeda, P.d.l., Muntané Relat, J., Wiedmer, T., Apostolova, N. y Tschan, M.P. (2020). Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot. Biology, 9 (3) | |
dc.identifier.issn | 2079-7737 | es |
dc.identifier.uri | https://hdl.handle.net/11441/100467 | |
dc.description | Este artículo pertenece a un número especial: Autophagy in Cancer | es |
dc.description.abstract | Autophagy is a highly conserved degradation mechanism that is essential for maintaining
cellular homeostasis. In human disease, autophagy pathways are frequently deregulated and
there is immense interest in targeting autophagy for therapeutic approaches. Accordingly, there
is a need to determine autophagic activity in human tissues, an endeavor that is hampered by the
fact that autophagy is characterized by the flux of substrates whereas histology informs only about
amounts and localization of substrates and regulators at a single timepoint. Despite this challenging task, considerable progress in establishing markers of autophagy has been made in recent years.
The importance of establishing clear-cut autophagy markers that can be used for tissue analysis
cannot be underestimated. In this review, we attempt to summarize known techniques to quantify
autophagy in human tissue and their drawbacks. Furthermore, we provide some recommendations
that should be taken into consideration to improve the reliability and the interpretation of autophagy
biomarkers in human tissue samples | es |
dc.description.sponsorship | Institute de Salud Carlos III (ISCIII) y Fondos FEDER de la UE PI14/01085 y PI17/00093 | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades RTI2018-096748-B-100 to N.A. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades FPU17/00026 | es |
dc.description.sponsorship | Consejería de Igualdad, Salud y Políticas Sociales PI-0198-2016 | es |
dc.description.sponsorship | Fondos FEDER de la UE NORTE-01-0145-FEDER-000013 y los proyectos POCI-01-0145-FEDER-028159 y POCI-01-0145-FEDER-030782 | es |
dc.format | application/pdf | es |
dc.format.extent | 24 | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Biology, 9 (3) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Autophagy | es |
dc.subject | Biomarkers | es |
dc.subject | Pathology | es |
dc.subject | Disease | es |
dc.title | Assessing Autophagy in Archived Tissue or How to Capture Autophagic Flux from a Tissue Snapshot | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.publisherversion | https://doi.org/10.3390/biology9030059 | es |
dc.identifier.doi | 10.3390/biology9030059 | es |
dc.journaltitle | Biology | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 3 | es |