Artículo
DNA conformational changes induced by cationic gemini surfactants: the key to switching DNA compact structures into elongated forms
Autor/es | Grueso Molina, Elia María
Kuliszewska, Edyta Roldán González, Emilio Pérez Tejeda, María del Pilar Prado Gotor, Rafael Brecker, Lothar |
Departamento | Universidad de Sevilla. Departamento de Química Física |
Fecha de publicación | 2015 |
Fecha de depósito | 2019-06-18 |
Publicado en |
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Resumen | The DNA conformational changes induced by different members of the N,N0-bis(dimethyldodecyl)-a-ualkanediammonium
dibromide series (m-s-m, m ¼ 12, s ¼ 3 and 6) and the analogous series of
hexadecyl gemini surfactants (m ... The DNA conformational changes induced by different members of the N,N0-bis(dimethyldodecyl)-a-ualkanediammonium dibromide series (m-s-m, m ¼ 12, s ¼ 3 and 6) and the analogous series of hexadecyl gemini surfactants (m ¼ 16, s ¼ 3 and 6) were investigated in aqueous media by means of circular dichroism (CD), zeta potential, dynamic light scattering (DLS), viscometry, and atomic force microscopy (AFM) methods. The measurements were carried out by varying the gemini surfactant–DNA molar ratio, R ¼ Cm-s-m/CDNA. For the conditions investigated two significantly different conformational changes were observed, the second of them being worth noting. At low molar ratios, all methods concurred by showing that gemini surfactants were able to form ordered aggregates which precedes DNA compaction. The second effect observed, at high molar ratios, corresponds to the transition from the compact state to a new more extended conformation. The degree of decompaction and the morphologies of the visualized structures are different not only depending on the surfactant tail's length, but also on the spacer's length. The results obtained for the 16-3-16/DNA and 16-6-16/DNA systems point out that the compaction/decompaction processes are somewhat different to those previously visualized for the analogous monoquaternary chain surfactant CTAB. |
Identificador del proyecto | FQM-03623 |
Cita | Grueso Molina, E.M., Kuliszewska, E., Roldán González, E., Pérez Tejeda, M.P., Prado Gotor, R. y Brecker, L. (2015). DNA conformational changes induced by cationic gemini surfactants: the key to switching DNA compact structures into elongated forms. RSC Advances, 5 (37), 29433-29446. |
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