dc.creator | Grueso Molina, Elia María | es |
dc.creator | Kuliszewska, Edyta | es |
dc.creator | Roldán González, Emilio | es |
dc.creator | Pérez Tejeda, María del Pilar | es |
dc.creator | Prado Gotor, Rafael | es |
dc.creator | Brecker, Lothar | es |
dc.date.accessioned | 2019-06-18T09:06:40Z | |
dc.date.available | 2019-06-18T09:06:40Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Grueso Molina, E.M., Kuliszewska, E., Roldán González, E., Pérez Tejeda, M.P., Prado Gotor, R. y Brecker, L. (2015). DNA conformational changes induced by cationic gemini surfactants: the key to switching DNA compact structures into elongated forms. RSC Advances, 5 (37), 29433-29446. | |
dc.identifier.issn | 2046-2069 | es |
dc.identifier.uri | https://hdl.handle.net/11441/87477 | |
dc.description.abstract | The DNA conformational changes induced by different members of the N,N0-bis(dimethyldodecyl)-a-ualkanediammonium
dibromide series (m-s-m, m ¼ 12, s ¼ 3 and 6) and the analogous series of
hexadecyl gemini surfactants (m ¼ 16, s ¼ 3 and 6) were investigated in aqueous media by means of
circular dichroism (CD), zeta potential, dynamic light scattering (DLS), viscometry, and atomic force
microscopy (AFM) methods. The measurements were carried out by varying the gemini surfactant–DNA
molar ratio, R ¼ Cm-s-m/CDNA. For the conditions investigated two significantly different conformational
changes were observed, the second of them being worth noting. At low molar ratios, all methods
concurred by showing that gemini surfactants were able to form ordered aggregates which precedes
DNA compaction. The second effect observed, at high molar ratios, corresponds to the transition from
the compact state to a new more extended conformation. The degree of decompaction and the
morphologies of the visualized structures are different not only depending on the surfactant tail's length,
but also on the spacer's length. The results obtained for the 16-3-16/DNA and 16-6-16/DNA systems
point out that the compaction/decompaction processes are somewhat different to those previously
visualized for the analogous monoquaternary chain surfactant CTAB. | es |
dc.description.sponsorship | Consejería de Educación y Ciencia of the Junta de Andalucía FQM-03623 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Royal Society of Chemistry | es |
dc.relation.ispartof | RSC Advances, 5 (37), 29433-29446. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | DNA | es |
dc.subject | ADN | es |
dc.title | DNA conformational changes induced by cationic gemini surfactants: the key to switching DNA compact structures into elongated forms | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Física | es |
dc.relation.projectID | FQM-03623 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1039/c5ra03944d | es |
dc.identifier.doi | 10.1039/c5ra03944d | es |
idus.format.extent | 14 p. | es |
dc.journaltitle | RSC Advances | es |
dc.publication.volumen | 5 | es |
dc.publication.issue | 37 | es |
dc.publication.initialPage | 29433 | es |
dc.publication.endPage | 29446 | es |
dc.identifier.sisius | 21078561 | es |