Artículo
Reelin is involved in the crypt-villus unit homeostasis
Autor/es | García Miranda, Pablo
Vázquez Carretero, María Dolores Sesma, Pilar Peral Rubio, María José Ilundáin Larrañeta, María Anunciación Ana |
Departamento | Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2013 |
Fecha de depósito | 2023-11-30 |
Publicado en |
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Resumen | Intestinal myofibroblasts secrete substances that control organogenesis and wound repair of the intestine. The myofibroblasts of the rat small intestine express reelin and the present work explores whether reelin regulates ... Intestinal myofibroblasts secrete substances that control organogenesis and wound repair of the intestine. The myofibroblasts of the rat small intestine express reelin and the present work explores whether reelin regulates crypt-villus unit homeostasis using normal mice and mice with the reelin gene disrupted (reeler). The results reveal that mouse small intestine expresses reelin, its receptors apolipoprotein E receptor 2 (ApoER2) and very low-density lipoprotein receptor (VldlR) and the reelin effector protein Disabled-1 (Dab1) and that reelin expression is restricted to myofibroblasts. The absence of reelin significantly reduces epithelial cell proliferation, migration, and apoptosis and the number of Paneth cells. These effects are observed during the suckling, weaning, and adult periods. The number of Goblet cells is increased in the 2-month-old reeler mice. The absence of reelin also expands the extracellular space of the adherens junctions and desmosomes without significantly affecting either the tight-junction structure or the epithelial paracellular permeability. In conclusion, this is the first in vivo work showing that the absence of reelin alters intestinal epithelium homeostasis. |
Agencias financiadoras | Junta de Andalucía |
Identificador del proyecto | CTS 5884 |
Cita | García Miranda, P., Vázquez Carretero, M.D., Sesma, P., Peral Rubio, M.J. y Ilundáin Larrañeta, M.A.A. (2013). Reelin is involved in the crypt-villus unit homeostasis. Tissue Engineering - Part A., 19 (1-2), 188-198. https://doi.org/10.1089/ten.tea.2012.0050. |
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Reelin Is Involved.pdf | 1.192Mb | [PDF] | Ver/ | |