Ponencias (Bioquímica Vegetal y Biología Molecular)
URI permanente para esta colecciónhttps://hdl.handle.net/11441/10826
Examinar
Envíos recientes
Ponencia Discovery of Genes Implied in Cancer by Genetic Algorithms and Association Rules(Springer, 2016) Sánchez Medina, Alejandro; Gil Pichardo, Alberto; García Heredia, José Manuel; Martínez Ballesteros, María del Mar; Universidad de Sevilla. Departamento de Lenguajes y Sistemas Informáticos; Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular; Ministerio de Ciencia Y Tecnología (MCYT). España; Ministerio de Economía y Competitividad (MINECO). España; Junta de Andalucía; Universidad de Sevilla. TIC-254: Data Science and Big Data LabThis work proposes a methodology to identify genes highly related with cancer. In particular, a multi-objective evolutionary algo rithm named CANGAR is applied to obtain quantitative association rules. This kind of rules are used to identify dependencies between genes and their expression levels. Hierarchical cluster analysis, fold-change and review of the literature have been considered to validate the relevance of the results obtained. The results show that the reported genes are consistent with prior knowledge and able to characterize cancer colon patients.Ponencia Litio como terapia neuroprotectora en el modelo appsl/ps1m146l de la enfermedad de Alzheimer(2013) Trujillo Estrada, Laura Isabel; Castro, Vanesa de; Jiménez Muñoz, Sebastián; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Universidad de Sevilla. Departamento de Bioquímica y Biología MolecularEl litio se utiliza desde hace varias décadas en el tratamiento de trastornos bipolares y la depresión, y recientemente se debate su uso potencial en patologías neurodegenerativas como la enfermedad de Alzheimer (AD).Ponencia Contribution of phenotypic heterogeneity to adaptive antibiotic resistance(National Academy os Sciencies, 2013) Muñóz-Marín, Maria del Carmen; Luque Romero, Ignacio; Zubkov, Mikhail V.; Hill, Polly G.; Diez, Jesús; García-Fernandez, Manuel; Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología MolecularProchlorococcus is responsible for a significant part of CO2 fixation in the ocean. Although it was long considered an autotrophic cyanobacterium, the uptake of organic compounds has been reported, assuming they were sources of limited biogenic elements. We have shown in laboratory experiments that Prochlorococcus can take up glucose. However, the mechanisms of glucose uptake and its occurrence in the ocean have not been shown. Here, we report that the gene Pro1404 confers capability for glucose uptake in Prochlorococcus marinus SS120. We used a cyanobacterium unable to take up glucose to engineer strains that express the Pro1404 gene. These recombinant strains were capable of specific glucose uptake over a wide range of glucose concentrations, showing multiphasic transport kinetics. The Ks constant of the high affinity phase was in the nanomolar range, consistent with the average concentration of glucose in the ocean. Furthermore, we were able to observe glucose uptake by Prochlorococcus in the central Atlantic Ocean, where glucose concentrations were 0.5-2.7 nM. Our results suggest that Prochlorococcus are primary producers capable of tuning their metabolism to energetically benefit from environmental conditions, taking up not only organic compounds with key limiting elements in the ocean, but also molecules devoid of such elements, like glucose.Ponencia Biología molecular de la asimilación de amonio en cianobacterias(1999) Florencio Bellido, Francisco Javier; Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular