Datos de Investigación (Fisiología Médica y Biofísica)
URI permanente para esta colecciónhttps://hdl.handle.net/11441/170016
Examinar
Envíos recientes
Conjunto de Datos Dataset of "Long-term consequences of adolescent methylphenidate exposure on sustained attention and prelimbic PV+ interneuron maturation in rats"(2026) Pérez-Colorado, Antonio; López García, Juan Carlos; Martínez-Marín, Reyes; Vargas Romero, Juan Pedro; Díaz Argandoña, Estrella; Psicología Experimental; Fisiología Médica y Biofísica; Pérez-Colorado, Antonio; Díaz Argandoña, Estrella; Pérez-Colorado, Antonio; Pérez-Colorado, Antonio; Díaz Argandoña, Estrella; Ministerio de Ciencia, Innovación y Universidades (MICIU). España; HUM646: Aprendizaje y CogniciónIn this research, we investigated how chronic exposure to methylphenidate (MPH) during adolescence affects the maturation of the medial prefrontal cortex (mPFC), with a specific focus on parvalbumin-expressing (PV+) interneurons and long-term attentional performance. Wistar rats of both sexes received therapeutically relevant doses of MPH during distinct adolescent developmental windows and were later assessed in adulthood using a sustained attention task (SAT) to evaluate potential persistent cognitive effects. This dataset contains behavioral performance measures from the SAT (hit rate, correct rejection rate, omissions, reaction time, and performance under varying stimulus durations), along with quantified counts of PV+ interneurons in prelimbic and infralimbic mPFC regions. Additional variables include sex, treatment dose, developmental exposure window, age at treatment onset, and control groups. The dataset enables analysis of how developmental MPH exposure influences GABAergic maturation and adult attentional function.