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Listar por autor "Vitorica Ferrández, Francisco Javier"
Mostrando ítems 1-20 de 60
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Artículo
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus
Sánchez Varo, Raquel María; Trujillo Estrada, Laura Isabel; Sánchez Mejías, Elisabeth; Torres Canalejo, Manuel; Baglietto Vargas, David; Moreno González, Inés; Jiménez Muñoz, Sebastián; Ruano Caballero, Diego; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Springer, 2012)Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease ...
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Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo
Serrano Pozo, Alberto; Sánchez García, Manuel A.; Heras Garvín, Antonio; March Díaz, Rosana Rocío; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; López Barneo, José; Vitorica Ferrández, Francisco Javier; Pascual, Alberto (Public Library of Science, 2017)Background Recent epidemiological evidence has linked hypoxia with the development of Alzheimer disease (AD). A number ...
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Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model
Jiménez Muñoz, Sebastián; Torres Canalejo, Manuel; Vizuete Chacón, María Luisa; Sánchez Varo, Raquel María; Sánchez Mejías, Elisabeth; Trujillo Estrada, Laura Isabel; Carmona Cuenca, Irene; Caballero, Cristina M.; Ruano Caballero, Diego; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (American Society for Biochemistry and Molecular Biology Inc., 2011)Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, ...
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Artículo
Amyloid-β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease
Sánchez Mico, María; Jiménez Muñoz, Sebastián; Gómez Arboledas, Ángela; Muñoz Castro, Clara; Romero Molina, Carmen; Navarro Garrido, Victoria; Vizuete Chacón, María Luisa; Vitorica Ferrández, Francisco Javier (Wiley, 2020)Reactive astrocytes and dystrophic neurites, most aberrant presynaptic elements, are found surrounding amyloid-β plaques ...
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Amyloid-β reduces the expression of neuronal FAIM-L, thereby shifting the inflammatory response mediated by TNFα from neuronal protection to death
Carriba, Paulina; Jiménez Muñoz, Sebastián; Navarro, Victoria; Moreno González, Inés; Barneda Zahonero, Bruna; Vitorica Ferrández, Francisco Javier (Nature Publishing Group, 2015)The brains of patients with Alzheimer's disease (AD) present elevated levels of tumor necrosis factor-α (TNFα), a cytokine ...
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Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease
González Domínguez, Raúl; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis (Elsevier, 2015)Metabolomic analysis of brain tissue from transgenic mouse models of Alzheimer's disease has demonstrated a great potential ...
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Artículo
Aβ oligomers trigger necroptosis-mediated neurodegeneration via microglia activation in Alzheimer’s disease
Salvadores, Natalia; Moreno González, Inés; Gámez, Nazaret; Quiroz, Gabriel; Vegas Gómez, Laura; Escandón, Marcela; Jiménez Muñoz, Sebastián; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia; Soto, Claudio; Court, Felipe A. (BMC, 2022)Alzheimer’s disease (AD) is a major adult-onset neurodegenerative condition with no available treatment. Compelling reports ...
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Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-β-Induced Neuronal Death
Fernández, Ana M.; Hervás, Rubén; Domínguez Fraile, Manuel; Garrido Navarro, Victoria; Gómez Gutiérrez, Patricia; Vega, Miguel; Torres Alemán, Ignacio; Vitorica Ferrández, Francisco Javier (IOS Press, 2016-06-07)Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
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Artículo
Blockade of the Interaction of Calcineurin with FOXO in Astrocytes Protects Against Amyloid-βInduced Neuronal Death
Navarro Garrido, Victoria; Vitorica Ferrández, Francisco Javier; Fernández, Ana M.; Hervasa, Rubén; Gómez Gutiérrez, Patricia; Vega, Miguel (IOS Press, 2016)Astrocytes actively participate in neuro-inflammatory processes associated to Alzheimer’s disease (AD), and other brain ...
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Tesis Doctoral
Caracterización de la respuesta y función astroglial en modelos y pacientes de la enfermedad de Alzheimer.
Sánchez Mico, María (2019-03-25) -
Tesis Doctoral
Caracterización de los sistemas gabaérgico y colinérgico en hipocampo de ratones transgénicos modelos de la enfermedad de Alzheimer
Ramos Prieto, Blanca (2005-07-22) -
Tesis Doctoral
Caracterización de los sistemas gabaérgico y colinérgico en neocorteza de ratones transgénicos modelos de la enfermedad de Alzheimer
Río Valencia, Juan Carlos del (2005-07-22) -
Tesis Doctoral
Caracterización farmacológica de la proteína receptora GABAA en el sistema nervioso de la rata: Efecto del envejecimiento
Ruano Caballero, Diego (1993-02-12)La caracterización farmacológica de la proteína receptora GABAA, ha puesto de manifiesto la existencia de tres sitios de ...
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Artículo
Cytotoxicity and Effects on the Synapsis Induced by Pure Cylindrospermopsin in an E17 Embryonic Murine Primary Neuronal Culture in a Concentration-and Time-Dependent Manner
Hinojosa, María Gracia; Prieto Ortega, Ana Isabel; Muñoz Castro, Clara; Sánchez Mico, María; Vitorica Ferrández, Francisco Javier; Cameán Fernández, Ana María; Jos Gallego, Ángeles Mencía (Multidisciplinary Digital Publishing Institute (MDPI), 2022)Cylindrospermopsin (CYN) is a cyanotoxin whose incidence has been increasing in the last decades. Due to its capacity to ...
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Artículo
Deciphering metabolic abnormalities associated with Alzheimer's disease in the APP/PS1 mouse model using integrated metabolomic approaches
González Domínguez, Raúl; García Barrera, Tamara; Vitorica Ferrández, Francisco Javier; Gómez Ariza, José Luis (Elsevier, 2015)The transgenic mouse APP/PS1 is widely employed by neuroscientists because reproduces well some of the neuropathological ...
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Artículo
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus
Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Carmona Cuenca, Irene; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Sánchez Varo, Raquel María; Torres Canalejo, Manuel; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria (2012)Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies ...
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Artículo
Disruption of Amyloid Plaques Integrity Affects the Soluble Oligomers Content from Alzheimer Disease Brains
Jiménez Muñoz, Sebastián; Navarro Garrido, Victoria; Moyano González, Francisco Javier; Sánchez Mico, María; Torres Canalejo, Manuel; Dávila Cansino, José Carlos; Vizuete Chacón, María Luisa; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier (Public Library of Science, 2014)The implication of soluble Abeta in the Alzheimer's disease (AD) pathology is currently accepted. In fact, the content of ...
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Artículo
Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients
Sánchez Mejías, Elisabeth; Núñez Díaz, Cristina; Sánchez Varo, Raquel María; Gómez Arboledas, Ángela; García León, Juan Antonio; Fernández Valenzuela, Juan José; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Wiley Open Access, 2019)Neuronal loss is the best neuropathological substrate that correlates with cortical atrophy and dementia in Alzheimer’s ...
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Artículo
Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
Romero Molina, Carmen; Navarro Garrido, Victoria; Sánchez Varo, Raquel María; Jiménez Muñoz, Sebastián; Fernández Valenzuela, Juan José; Sánchez Mico, María; Muñoz Castro, Clara; Gutiérrez Pérez, Antonia; Vitorica Ferrández, Francisco Javier; Vizuete Chacón, María Luisa (Frontiers Media Research Foundation, 2018-11-14)Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease ...
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Artículo
Dual roles of Aβ in proliferative processes in an amyloidogenic model of Alzheimer’s disease
Baglietto Vargas, David; Sánchez Mejías, Elisabeth; Navarro Garrido, Victoria; Jiménez Muñoz, Sebastián; Trujillo Estrada, Laura Isabel; Gómez Arboledas, Ángela; Sánchez Mico, María; Sánchez Varo, Raquel María; Vizuete Chacón, María Luisa; Dávila Cansino, José Carlos; García Verdugo, José Manuel; Vitorica Ferrández, Francisco Javier; Gutiérrez Pérez, Antonia (Nature Research (part of Springer Nature), 2017)Alzheimer’s disease is a major neurodegenerative disorder that leads to severe cognitive deficits in the elderly population. ...