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Listar por autor "Smani, Younes"
Mostrando ítems 1-20 de 24
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Artículo
AOA-2 Derivatives as Outer Membrane Protein A Inhibitors for Treatment of Gram-Negative Bacilli Infections
Ayerbe Algaba, Rafael; Bayó, Nuria; Verdú, Ester; Parra-Millán, Raquel; Seco, Jesús; Teixidó, Meritxell; Pachón Díaz, Jerónimo; Giralt, Ernest; Smani, Younes (Frontiers Media S.A., 2021)Previously, we identified that a cyclic hexapeptide AOA-2 inhibited the interaction of Gram-negative bacilli (GNB) like ...
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Artículo
Assessing the impact on intestinal microbiome and clinical outcomes of antibiotherapy optimisation strategies in haematopoietic stem cell transplant recipients: study protocol for the prospective multicentre OptimBioma study
Jiménez-Jorge, Silvia; Labrador-Herrera, Gema; Rosso-Fernández, Clara M.; Rodríguez-Torres, Nancy; Pachón-Ibáñez, María Eugenia; Smani, Younes; Espigado Tocino, Ildefonso (BMJ Publishing Group, 2020)Introduction: Haematopoietic stem cell transplantation (HSCT) is a life-saving treatment for a number of haematological ...
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Tesis Doctoral
Bacteriemias por Escherichia coli: análisis clínico-epidemiológico, de factores de patogenicidad y mecanismos de resistencia a betalactámicos/inhibidores de betalactamasas
Rodríguez Villodres, Ángel (2020-02-03)Las infecciones por bacterias multirresistentes son un serio problema a nivel mundial. La aparición constante de mecanismos ...
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Artículo
Combating virulence of Gramnegative bacilli by OmpA inhibition
Vila-Farrés, Xavier; Parra Millán, Raquel; Sánchez-Encinales, Viviana; Varese, Mónica; Ayerbe Algaba, Rafael; Bayó, Nuria; Pachón Díaz, Jerónimo; Smani, Younes (Nature Research, 2017)Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. ...
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Artículo
Efficacy of lysophosphatidylcholine as direct treatment in combination with colistin against acinetobacter baumannii in murine severe infections models
Miró-Canturri, Andrea; Ayerbe Algaba, Rafael; Jiménez-Mejías, Manuel Enrique; Pachón Díaz, Jerónimo; Smani, Younes (MDPI, 2021-02-17)The stimulation of the immune response to prevent the progression of an infection may be an adjuvant to antimicrobial ...
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Tesis Doctoral
Escherichia coli infection: mechanisms and rapid detection of resistance to the association of ß-lactams with ß-lactamase inhibitors, and impact of the Sars-Cov-2 pandemic on the morbidity and mortality of intra-abdominal infection
Gálvez Benítez, Lydia (2023-11-03)Infections by Escherichia coli in human beings produce a significant disease burden, with important morbidity and mortality, ...
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Artículo
Impact of the immune response modification by lysophosphatidylcholine in the efficacy of antibiotic therapy of experimental models of peritoneal sepsis and pneumonia by Pseudomonas aeruginosa: LPC therapeutic effect in combined therapy
Parra-Millán, Raquel; Jiménez-Mejías, Manuel E. ; Ayerbe-Algaba, Rafael; Domínguez-Herrera, Juan; Díaz, Caridad; Pérez del Palacio, José; Pachón, Jerónimo; Smani, Younes (Elsevier, 2022)Introduction: Immune response stimulation may be an adjuvant to antimicrobial treatment. Here, we evaluated the impact ...
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Artículo
Impaired Virulence and In Vivo Fitness of Colistin-Resistant Acinetobacter baumannii
López-Rojas, Rafael; Domínguez-Herrera, J.; Mcconnell, Michael; Docobo Pérez, Fernando; Smani, Younes; Pachón Díaz, Jerónimo (Oxford University Press, 2011-01-07)Acinetobacter baumannii (American Type Culture Collection strain 19606) acquires mutations in the pmrB gene during the in ...
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Artículo
In vitro Activity of Pentamidine Alone and in Combination With Aminoglycosides, Tigecycline, Rifampicin, and Doripenem Against Clinical Strains of Carbapenemase-Producing and/or Colistin-Resistant Enterobacteriaceae
Cebrero Cangueiro, Tania; Álvarez Marín, Rocío; Labrador Herrera, Gema; Smani, Younes; Cordero Matia, María Elisa (Frontiers Media SA, 2018-10-18)Enterobacteriaceae cause different types of community- and hospital-acquired infections. Moreover, the spread of ...
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Artículo
In vitro and in vivo virulence study of Listeria monocytogenes isolated from the Andalusian outbreak in 2019
Vila Domínguez, Andrea; Carretero Ledesma, Marta; Infante Domínguez, Carmen; Cisneros, José Miguel; Lepe Jiménez, José Antonio; Smani, Younes (MDPI, 2023-01-12)In 2019, the biggest listeriosis outbreak by Listeria monocytogenes (Lm) in the South of Spain was reported, resulting ...
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Artículo
Intracellular Trafficking and Persistence of Acinetobacter baumannii Requires Transcription Factor EB
Parra Millán, Raquel; Guerrero Gómez, David; Ayerbe Algaba, Rafael; Pachón Ibáñez, María Eugenia; Miranda Vizuete, Antonio; Pachón Díaz, Jerónimo; Smani, Younes (American Society for Microbiology, 2018-03-28)Acinetobacter baumannii is a significant human pathogen associated with hospital-acquired infections. While adhesion, an ...
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Artículo
iTRAQ-Based Quantitative Proteomic Analysis of Acinetobacter baumannii under Hypoxia and Normoxia Reveals the Role of OmpW as a Virulence Factor
Gil Marqués, María Luisa; Pachón Díaz, Jerónimo; Smani, Younes (American Society for Microbiology, 2022)Acinetobacter baumannii needs to adapt to hypoxia during infection. Understanding its proteome regulation during infection ...
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Patente. Invención
Kit y método de detección rápida de bacterias resistentes a las combinaciones de antibiótico β-lactámico con un inhibidor de β- lactamasa, y de la resistencia de expectro extendido a los β-lactámicos en aislados clínicos
Smani, Younes; Rodríguez Villodres, Ángel; Lepe Jiménez, José Antonio (Organización Mundial de la Propiedad Intelectual (OMPI), 2020-12-24)Método de identificación de aislados bacterianos resistentes a las combinaciones de antibiótico β-lactámico con inhibidores ...
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Tesis Doctoral
Non-antimicrobial strategies for the prevention and treatment of infections by multidrug-resistant gram-negative bacilli
Parra Millán, Raquel (2017-05-19)Due to the increased of antimicrobial resistance rates and the difficulty of having effective treatment for infections ...
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Artículo
Platelet-activating Factor Receptor Initiates Contact of Acinetobacter baumannii Expressing Phosphorylcholine with Host Cells
Smani, Younes; Docobo Pérez, Fernando; López Rojas, Rafael; Domínguez Herrera, Juan; Ibáñez Martínez, José; Pachón Díaz, Jerónimo (2012-06)Adhesion is an initial and important step in Acinetobacter baumannii causing infections. However, the exact molecular ...
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Artículo
Potential tamoxifen repurposing to combat infections by multidrug-resistant Gram-negative bacilli
Miró-Canturri, Andrea; Ayerbe Algaba, Rafael; Toro Estévez, Raquel del; Jiménez-Mejías, Manuel Enrique; Pachón Díaz, Jerónimo; Smani, Younes (2021-05-26)The development of new strategic therapies for multidrug-resistant bacteria, like the use of non-antimicrobial approaches ...
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Artículo
Prevalence and clinical impact of Streptococcus pneumoniae nasopharyngeal carriage in solid organ transplant recipients
Roca Oporto, Cristina; Cebrero Cangueiro, Tania; Gil Marqués, María Luisa; Labrador Herrera, Gema; Smani, Younes; González Roncero, Francisco Manuel; Pachón Díaz, Jerónimo; Pachón Ibáñez, María Eugenia; Cordero Matia, María Elisa (2019-08-06)Background: S. pneumoniae is the leading cause of community-acquired pneumonia in the solid organ transplant recipient ...
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Tesis Doctoral
Reposicionamiento de fármacos para el tratamiento de infecciones causadas por bacilos gramnegativos multirresistentes
Miró-Canturri, Andrea (2020-07-14)El aumento de bacterias multirresistentes y la dificultad de encontrar un tratamiento eficaz para este tipo de infecciones, ...
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Artículo
Repurposing of the Tamoxifen Metabolites to Treat Methicillin-Resistant Staphylococcus epidermidis and Vancomycin-Resistant Enterococcus faecalis Infections
Miró-Canturri, Andrea; Vila-Domínguez, Andrea; Caretero-Ledesma, Marta; Ayerbe Algaba, Rafael; Pachón Díaz, Jerónimo; Jiménez-Mejías, Manuel E.; Smani, Younes (American Society of Microbiology, 2021-10-20)Repurposing drugs provides a new approach to the fight against multidrug-resistant (MDR) bacteria. We have reported that ...
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Artículo
Role of blaTEM and OmpC in the piperacillin-tazobactam resistance evolution by E. coli in patients with complicated intra-abdominal infection
Galvez-Benitez, Lydia; Ortiz de la Rosa, Jose Manuel; Rodríguez-Villodres, Angel; Casimiro-Soriguer, Carlos S.; Molina-Panadero, Irene; Alvarez-Marín, Rocío; Bonnin, Remy A; Naas, Thierry; Pachón Díaz, Jerónimo; Cisneros, José Miguel; Lepe Jiménez, José Antonio; Smani, Younes (Elsevier, 2023)Piperacillin-tazobactam resistance (P/T-R) is increasingly reported among Escherichia coli isolates. Although in vitro ...