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Browsing by Author "Durán, Raúl V."
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Article
A Method for Unsupervised Semi-Quantification of Inmunohistochemical Staining with Beta Divergences
Sarmiento Vega, María Auxiliadora; Durán Díaz, Iván; Fondón García, Irene; Tomé, Mercedes; Bodineau, Clément; Durán, Raúl V. (MPDI, 2022-02)In many research laboratories, it is essential to determine the relative expression levels of some proteins of interest ...
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Article
A Robust Method for the Unsupervised Scoring of Immunohistochemical Staining
Durán Díaz, Iván; Sarmiento Vega, María Auxiliadora; Fondón García, Irene; Bodineau, Clément; Tomé, Mercedes; Durán, Raúl V. (MDPI, 2024-02)Immunohistochemistry is a powerful technique that is widely used in biomedical research and clinics; it allows one to ...
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Article
Glutamine, MTOR and autophagy: a multiconnection relationship
Bodineau, Clément; Tomé, Mercedes; Murdoch, Piedad del Socorro; Durán, Raúl V. (Taylor & Francis, 2022)Cancer cells metabolize glutamine mostly through glutaminolysis, a metabolic pathway that activates MTORC1. The AMPK-MTORC1 ...
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Article
Manganese is a physiologically relevant TORC1 activator in yeast and mammals
Nicastro, Raffaele; Gaillard, Hélène; Zarzuela, Laura; Peli-Gulli, Marie-Pierre; Fernández García, Elisabet; Tomé, Mercedes; García Rodríguez, Néstor; Durán, Raúl V.; De Virgilio, Claudio; Wellinger, Ralf Erik (eLife Sciences Publications, 2022)The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human ...