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Listar por autor "Fernández-Bolaños Guzmán, José María"
Mostrando ítems 21-40 de 61
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Patente. Invención
Derivados acilados de carbohidratos, métodos de obtención y usos de los mismos
Mellado Durán, Encarnación; Fernández-Bolaños Guzmán, José María; Maya Castilla, Inés; Escobar Niño, Almudena; Sánchez Barrionuevo, Leyre; Cánovas López, David; González Benjumea, Alejandro; López López, Óscar (Oficina Española de Patentes y Marcas (OEPM), 2016-10-20)Derivados acilados de carbohidratos, métodos de obtención y usos de los mismos. La presente invención describe derivados ...
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Patente. Invención
Derivados acilados de polifenoles y/o carbohidratos, métodos de obtención y usos de los mismos
Mellado Durán, Encarnación; Fernández-Bolaños Guzmán, José María; Maya Castilla, Inés; Escobar Niño, Almudena; Sánchez Barrionuevo, Leyre; Cánovas López, David; González Benjumea, Alejandro; López López, Óscar (Oficina Española de Patentes y Marcas (OEPM), 2016-10-03)Derivados acilados de polifenoles y/o carbohidratos, métodos de obtención y usos de los mismos. La presente invención ...
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Artículo
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
Matos, Ana M. de; Martins, Alice; Man,Teresa; Evans, David; Walter, Magnus; Oliveira, Maria Conceição; López López, Óscar; Fernández-Bolaños Guzmán, José María; Rauter, Amélia P. (MDPI, 2019)With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new ...
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Artículo
Development of tacrine clusters as positively cooperative systems for the inhibition of acetylcholinesterase
Evangelista, Tereza Cristina Santos; López López, Óscar; Ferreira, Sabrina Baptista; Fernández-Bolaños Guzmán, José María; Sydnes, Magne O.; Lindbäck, Emil (Taylor & Francis Open Access, 2021)The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers ...
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Artículo
Encased Gold Nanoparticle Synthesis as a Probe for Oleuropein Self-Assembled Structure Formation
Jiménez Ruiz, Aila; Prado Gotor, Rafael; Fernández-Bolaños Guzmán, José María; González Benjumea, Alejandro; Carnerero Panduro, José María (MDPI, 2020-12)Stable oleuropein-coated gold nanoparticles in aqueous media were synthesized for the first time. Oleuropein (OLE) ...
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Tesis Doctoral
Feniltio y fenilsulfinil glicósidos: síntesis de análogos de factoes Nod y de y de C-sulfocelobiosas
Gómez Bujedo, Silvia (1999)La presente Tesis Doctoral se encuadra dentro de los proyectos de investigación sobre Isotiocianato, tioamnio- y ...
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Artículo
Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer's Disease
De Matos, Ana M.; Blázquez Sánchez, M. Teresa; Bento Oliveira, Andreia; de Almeida, Rodrigo F.M.; Nunes, Rafael; Lopes, Pedro E.M.; Machuqueiro, Miguel; Cristóvão, Joana S.; López López, Óscar; Fernández-Bolaños Guzmán, José María; Amélia P. (American Chemical Society, 2020)Despite the rapidly increasing number of patients suffering from type 2 diabetes, Alzheimer's disease, and diabetes-induced ...
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Artículo
Identification of an acetyl esterase in the supernatant of the environmental strain Bacillus sp. HR21-6
Sánchez Barrionuevo, Leyre; Mateos, Jesús; Fernández Puente, Patricia; Begines Aguilar, Paloma; Fernández-Bolaños Guzmán, José María; Gutiérrez Pozo, Gabriel; Cánovas López, David; Mellado Durán, María Encarnación (Elsevier, 2022)Bacillus sp. HR21-6 is capable of the chemo- and regioselective synthesis of lipophilic partially acetylated phenolic ...
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Artículo
Inhibitory effect of olive phenolic compounds isolated from olive oil by-product on melanosis of shrimps
Lama Muñoz, Antonio; Gómez Carretero, Antonio; Rubio Senent, Fátima; Bermúdez Oria, Alejandra; Maya Castilla, Inés; Fernández-Bolaños Guzmán, José María; Vioque Cubero, Blanca; Fernández-Bolaños Guzmán, Juan (Multidisciplinary Digital Publishing Institute (MDPI), 2021)Melanosis is an unsolved problem of the crustacean industry and the cause of great loss of value. This study investigates ...
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Artículo
Investigation of the Enantioselectivity of Acetylcholinesterase and Butyrylcholinesterase upon Inhibition by Tacrine-iminosugar Heterodimers
Vaaland, I. Caroline; López López, Óscar; Puerta, Adrián; Fernandes, Miguel X.; Padrón, José M.; Fernández-Bolaños Guzmán, José María; Sydnes, Magne O.; Lindback, Emil (Taylor & Francis, 2023)The copper-catalysed azide-alkyne cycloaddition was applied to prepare three enantiomeric pairs of heterodimers containing ...
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Artículo
Isolation and identification of minor secoiridoids and phenolic components from thermally treated olive oil by-products
Rubio Senent, Fátima; Martos, Sergio; Lama Muñoz, Antonio; Fernández-Bolaños Guzmán, José María; Rodríguez Gutiérrez, Guillermo; Fernández Bolaños, Juan (Elsevier, 2015-11-15)The application of an industrial process based on the hydrothermal treatment of 160 °C/60 min of alperujo, a by-product ...
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Artículo
Masked Phenolic-Selenium Conjugates: Potent and Selective Antiproliferative Agents Overcoming P-gp Resistance
Begines Aguilar, Paloma; Sevilla Horrillo, Lucía; Puerta, Adrián; Puckett, Rebeca; Bayort, Samuel; Lagunes, Irene; Maya Castilla, Inés; Padrón, José M.; López López, Óscar; Fernández-Bolaños Guzmán, José María (MDPI, 2020)Cancer accounts for one of the most complex diseases nowadays due to its multifactorial nature. Despite the vast number ...
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Artículo
N-1,2,3-triazole-isatin derivatives for cholinesterase and β-amyloid aggregation inhibition: A comprehensive bioassay study
Marques, Carolina S.; López López, Óscar; Bagetta, Donatella; Carreiro, Elisabete P.; Petralla, Sabrina; Bartolini, Manuela; Hoffmann, Matthias; Alcaro, Stefano; Monti, Barbara; Bolognesi, Maria Laura; Decker, Michael; Fernández-Bolaños Guzmán, José María; Burke, Anthony J. (Elsevier, 2020-05)Our goal was the evaluation of a series of N-1,2,3-triazole-isatin derivatives for multi-target activity which included ...
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Artículo
N-Substituted 3-Aminooxindoles and N-Propargyl Derivatives: Potential Biological Activities against Alzheimer's Disease
Hofmanova, Tereza; Marques, Carolina; García-Sosa, Alfonso T.; López López, Óscar; Leitzbach, Luisa; Carreiro, Elisabete P.; Fernández-Bolaños Guzmán, José María; Burke, Anthony J. (Elsevier, 2023-07-08)The oxindole core is an important structural motif in many natural and synthetic substances with various biological ...
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Artículo
New tacrine dimers with antioxidant linkers as dual drugs: Anti-Alzheimer's and antiproliferative agents
Roldán Peña, Jesús Miguel; Alejandre Ramos, Daniel; López López, Óscar; Maya Castilla, Inés; Lagunes, Irene; Padrón, José M.; Peña Altamira, Luis Emiliano; Bartolini, Manuela; Monti, Barbara; Bolognesi, Maria L.; Fernández-Bolaños Guzmán, José María (Elsevier, 2017)We have designed a series of tacrine-based homo- and heterodimers that incorporate an antioxidant tether (selenoureido, ...
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Patente. Invención
Nuevos antiiflamatorios basados en polifenoles del olivo
Fernández-Bolaños Guzmán, José María; Maya Castilla, Inés; González Benjumea, Alejandro; López García, María Ángeles; Alarcón de la Lastra Romero, Catalina; Villegas Lama, Isabel; Sánchez Fidalgo, Susana; Aparicio Soto, Marina (Oficina Española de Patentes y Marcas (OEPM), 2016-01-29)El objeto de la invención se centra en la síntesis por dos rutas alternativas del (3,4-dihidroxifenil)glicol (6), producto ...
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Artículo
Oleuropein and its peracetylated derivative negatively regulate osteoclastogenesis by controlling the expression of genes involved in osteoclast differentiation and function
Rosillo Ramírez, María de los Ángeles; Montserrat de la Paz, Sergio; Abia González, María del Rocío; Castejón Martínez, María Luisa; Millán-Linares, María del Carmen; Alarcón de la Lastra Romero, Catalina; Fernández-Bolaños Guzmán, José María; Muriana, Francisco J. G. (Royal Society of Chemistry, 2020)During chronic inflammation, macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-κB ...
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Artículo
Olive-Oil-Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF-κB Pathway
Aparicio Soto, Marina; Redhu, Davender; Sánchez Hidalgo, Marina; Fernández-Bolaños Guzmán, José María; Alarcón de la Lastra Romero, Catalina; Worm, Margitta; Babina, Magda (Wiley, 2019)Primary human keratinocytes are pretreated with HTy-Ac or HTy for 30 min and stimulated with IL-1β or Toll-like receptor ...
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Artículo
Osteoarthritis treatment with a novel nutraceutical acetylated ligstroside aglycone, a chemically modified extra-virgin olive oil polyphenol
Andrés, María C de; Meiss, Mia S; Sánchez Hidalgo, Marina; González Benjumea, Alejandro; Fernández-Bolaños Guzmán, José María; Alarcón de la Lastra Romero, Catalina; Oreffo, Richard OC (Sage, 2020)Recent studies have shown that dietary patterns confer protection from certain chronic diseases related to oxidative stress, ...
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Tesis Doctoral
Polihidroxialquil nitroimidazoles
Delgado Cobos, Pedro (1976-03-11)