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Browsing by Author "Burgos Morón, Estefanía"
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Article
Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine Derivatives as Potential Anticancer Agents-In Vitro Evaluation against Breast Cancer Cells
Guillén Mancina, Emilio; García Lozano, María del Rosario; Burgos Morón, Estefanía; Mazzotta, Sarah; Martínez Aguado, Pablo; Calderón Montaño, José Manuel; Vega Pérez, José Manuel; López Lázaro, Miguel; Iglesias Guerra, Fernando; Vega Holm, Margarita (MDPI, 2023)first_pagesettingsOrder Article Reprints Open AccessArticle Repurposing Study of 4-Acyl-1-phenylaminocarbonyl-2-substituted-piperazine ...
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Article
Role of the Intracellular pH in the Metabolic Switch between Oxidative Phosphorylation and AerobicGlycolysis - Relevance to Cancer
Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Pérez Guerrero, María Concepción; Salvador Bofill, Francisco Javier; Robles Frías, Antonio; López Lázaro, Miguel (Biomedical Publisher, 2011)Cellular energy in the form of ATP can be produced through oxidative phosphorylation and through glycolysis. Since ...
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Article
Screening for selective anticancer activity of 65 extracts of plants collected in Western Andalusia, Spain
Calderón Montaño, José Manuel; Martínez Sánchez, Sara María; Jiménez González, Víctor; Burgos Morón, Estefanía; Guillén Mancina, Emilio; Jiménez Alonso, Julio José; Díaz Ortega, Patricia; García Martín, Felipe José; Aparicio Martínez, Abelardo; López Lázaro, Miguel (Multidisciplinary Digital Publishing Institute (MDPI), 2021)Finding cytotoxic drugs with a high selectivity towards cancer cells is crucial to improve the low survival rates of ...
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Article
Screening for selective anticancer activity of plants from Grazalema Natural Park, Spain
Calderón Montaño, José Manuel; Martínez Sánchez, Sara María; Burgos Morón, Estefanía; Guillén Mancina, Emilio; Jiménez Alonso, Julio José; García Martín, Felipe José; Aparicio Martínez, Abelardo; López Lázaro, Miguel (Taylor & Francis, 2019-12-02)Since plants are an important source of anticancer drugs, we have carried out a random screening for selective anticancer ...
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Article
Selective cytotoxic activity and DNA damage by an epoxyalkyl galactopyranoside
Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; Orta Vázquez, Manuel Luis; Jiménez Alonso, Julio José; Vega Holm, Margarita; Vega Pérez, José Manuel; Iglesias Guerra, Fernando; Mateos Cordero, Santiago; López Lázaro, Miguel; Calderón Montaño, José Manuel (Wiley, 2018)Several clinically useful anticancer drugs selectively kill cancer cells by inducing DNA damage; the genomic instability ...
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Article
The Cardiac Glycosides Digitoxin, Digoxin and Ouabain Induce a Potent Inhibition of Glycolysis in Lung Cancer Cells
Calderón Montaño, José Manuel; Burgos Morón, Estefanía; López Lázaro, Miguel (Biomedical Publisher, 2013)Cardiac glycosides are promising anticancer drugs. We have recently shown that the cardiac glycosides digitoxin, digoxin ...
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Article
The Cockayne syndrome protein B is involved in the repair of 5-AZA-2′-deoxycytidine-induced DNA lesions
Burgos Morón, Estefanía; Calderón Montaño, José Manuel; Pastor Carrillo, Nuria María; Ruiz Castizo, Ángel; Domínguez García, Inmaculada; López Lázaro, Miguel; Mateos Cordero, Santiago; Orta Vázquez, Manuel Luis (Impact Journals, 2018)The Cockayne Syndrome Protein B (CSB) plays an essential role in Transcription-Coupled Nucleotide Excision Repair (TC-NER) ...
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Article
The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions
Orta Vázquez, Manuel Luis; Calderón Montaño, José Manuel; Domínguez García, Inmaculada; Burgos Morón, Estefanía; Pastor Carrillo, Nuria María; López Lázaro, Miguel; Helleday, Thomas (Oxford University Press, 2014)Decitabine (5-aza-21-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid ...
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Article
Vitamin C and the Red Wine Polyphenol Resveratrol - but not Curcumin and the Glycolysis Inhibitors 2- Deoxyglucose, Dichloroacetate and 3-Bromopyruvate - Induce Selective Cytotoxicity against Lung Cancer Cells.
Calderón Montaño, José Manuel; Burgos Morón, Estefanía; Martínez Sánchez, Sara María; López Lázaro, Miguel (Biomedical Publisher, 2013)Cancer statistics show that the most commonly diagnosed cancer in the world is lung cancer, that over 50% of patients ...
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Article
Zebularine induces replication-dependent double-strand breaks which are preferentially repaired by homologous recombination
Orta Vázquez, Manuel Luis; Pastor Carrillo, Nuria María; Burgos Morón, Estefanía; Domínguez García, Inmaculada; Calderón Montaño, José Manuel; Huertas Castaño, Carlos; López Lázaro, Miguel; Helleday, Thomas; Mateos Cordero, Santiago (Elsevier, 2017)Zebularine is a second-generation, highly stable hydrophilic inhibitor of DNA methylation with oral bioavailability that ...