Farmacia y Tecnología Farmacéutica

URI permanente para esta comunidadhttps://hdl.handle.net/11441/11019

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Mostrando 1 - 5 de 5

Evaluating the Potential of Ultrasound-assisted Compression for Crafting Implantable Drug Delivery Systems
(Elsevier, 2025) Millán Jiménez, Mónica; Sánchez Díaz, Elena; Mora Castaño, Gloria; Kurnia Anjani, Qonita; García Martín, Adela; Caraballo Rodríguez, Isidoro; Larrañeta, Eneko; Domínguez Robles, Juan; Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica; Ministerio de Ciencia e Innovación (MICIN). España; Universidad de Sevilla; Engineering and Physical Sciences Research Council (UK)
This study aimed to evaluate the feasibility of using ultrasound-assisted compression (USAC) for manufacturing implantable drug delivery systems (IDDS). USAC integrates the principles of traditional compression techniques with the application of ultrasound waves. The combined mechanical pressure and thermal energy generated by this technology result in material heating, melting, and sintering. This work investigates how the combination of ultrasound waves and a formulation comprising thermoplastic polyurethane (TPU) and low molecular weight polycaprolactone (L-PCL) influences the final properties of an implantable device designed for the sustained release of dipyridamole (DIP). The USAC-fabricated implants were thoroughly characterized to assess the material properties and the impact of the USAC technique. A comprehensive analysis was performed, including microscopy techniques such as Raman microscopy, acoustic microscopy, scanning electron microscopy (SEM), and optical coherence tomography (OCT), as well as X-ray Microcomputer Tomography (μCT). Additionally, thermal analysis, along with Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD), was performed to assess the interactions between the components and evaluate the crystallinity of the materials. Moreover, the mechanical properties and DIP release profiles of the implants were evaluated to study the feasibility of the USAC technique for manufacturing IDDS. The results suggested that the resulting materials were homogeneous, and non-covalent interactions between DIP and TPU were identified. These materials offered an attractive option for preparing TPU-based implantable devices due to their mechanical properties. Indeed, the addition of DIP in concentrations up to 20 % did not influence the compression modulus. In vitro release study demonstrated that the USAC-fabricated implants exhibited a sustained drug release profile throughout the 4-week study. Nevertheless, implants containing lower DIP loading exhibited a higher percentage release (6.29 %) compared to those with higher DIP loading (4.28 %), suggesting that the drug may be interacting with TPU within the USAC implantable devices, potentially limiting the release of DIP.
Microneedle array-based electrochemical sensor functionalized with SWCNTs for the highly sensitive monitoring of MDMA in interstitial fluid
(Elsevier, 2023-10) Drăgan, Ana Maria; Parrilla, Marc; Cambré, Sofie; Domínguez Robles, Juan; Detamornrat, Usanee; Donnelly, Ryan F.; Oprean, Radu; Cristea, Cecilia; De Wael, Karolien; Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica; European Union (UE); Engineering and Physical Sciences Research Council (UK); Fund for Scientific Research (FWO). Belgium; Ministerio de Ciencia e Innovación (MICIN). España
Illicit drug consumption constitutes a great concern worldwide due to its increased spread and abuse, and the negative consequences exerted on society. For instance, 3,4-methylenedioxymethamphetamine (MDMA), a synthetic amphetamine-type substance, was abused by 20 million people worldwide in 2020. This psychoactive substance exerts a myriad of effects on the human body being dangerous for the consumer’s health. Besides, MDMA has been used in the treatment of some psychiatric conditions. Therefore, the development of wearable devices for MDMA sensing in biological fluids is of great importance for forensic toxicology (e.g., monitoring of patients with suspected or known MDMA consumption) as well as for therapeutic management of patients. Herein, we report the development of a wearable electrochemical platform based on a hollow microneedle (MN) array sensor for the monitoring of MDMA in the interstitial fluid by square-wave voltammetry. First, the holes of the MN array were modified with conductive pastes to devise a MN patch with a three-electrode system. Subsequently, the functionalization of the working electrode with nanomaterials enhanced MDMA detection. Thereafter, analytical parameters were evaluated exhibiting a slope of 0.05 µA µM−1 within a linear range from 1 to 50 µM and a limit of detection of 0.75 µM in artificial interstitial fluid. Importantly, critical parameters such as selectivity, piercing capability, temperature, reversibility and stability were assessed. Overall, the obtained MN sensor exhibited excellent analytical performance, making it a promising tool for MDMA tracking in interstitial fluid for individuals on probation or under therapeutic treatment.
Microneedle Array-based Electrochemical Sensor Functionalized with SWCNTs for the Highly Sensitive Monitoring of MDMA in Interstitial Fluid
(Elsevier, 2023) Drăgan, Ana Maria; Parrilla, Marc; Cambré, Sofie; Domínguez Robles, Juan; Detamornrat, Usanee; Donnelly, Ryan F.; Oprean, Radu; Cristea, Cecilia; De Wael, Karolien; Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica; European Union (UE). H2020; Engineering and Physical Sciences Research Council (UK); Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca; Research Foundation Flanders (FWO); Ministerio de Ciencia e Innovación (MICIN). España
Illicit drug consumption constitutes a great concern worldwide due to its increased spread and abuse, and the negative consequences exerted on society. For instance, 3,4-methylenedioxymethamphetamine (MDMA), a synthetic amphetamine-type substance, was abused by 20 million people worldwide in 2020. This psychoactive substance exerts a myriad of effects on the human body being dangerous for the consumer’s health. Besides, MDMA has been used in the treatment of some psychiatric conditions. Therefore, the development of wearable devices for MDMA sensing in biological fluids is of great importance for forensic toxicology (e.g., monitoring of patients with suspected or known MDMA consumption) as well as for therapeutic management of patients. Herein, we report the development of a wearable electrochemical platform based on a hollow microneedle (MN) array sensor for the monitoring of MDMA in the interstitial fluid by square-wave voltammetry. First, the holes of the MN array were modified with conductive pastes to devise a MN patch with a three-electrode system. Subsequently, the functionalization of the working electrode with nanomaterials enhanced MDMA detection. Thereafter, analytical parameters were evaluated exhibiting a slope of 0.05 µA µM−1 within a linear range from 1 to 50 µM and a limit of detection of 0.75 µM in artificial interstitial fluid. Importantly, critical parameters such as selectivity, piercing capability, temperature, reversibility and stability were assessed. Overall, the obtained MN sensor exhibited excellent analytical performance, making it a promising tool for MDMA tracking in interstitial fluid for individuals on probation or under therapeutic treatment.
Preparation, Characterisation, and Testing of Reservoir-based Implantable Devices Loaded with Tizanidine and Lidocaine
(Springer, 2025) Picco, Camila J.; Bhalerao, Mihir S.; Fandino, Octavio E.; Magill, Elizabeth R.; Anjani, Qonita Kurnia; Acheson, Jonathan G.; Donnelly, Ryan F.; Domínguez Robles, Juan; Larrañeta, Eneko; Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica; Engineering and Physical Sciences Research Council (UK); Ministerio de Ciencia, Innovación y Universidades (MICIU). España; Universidad de Sevilla
Multiple sclerosis is a chronic neuroimmunological disorder that causes progressive disability, primarily in young adults. It places a significant burden on healthcare systems due to high medication costs and long-term care needs. Implantable devices offer a promising alternative for delivering sustained drug doses in the treatment of chronic conditions. This study introduces a novel long-acting subcutaneous implant for dual-drug delivery: tizanidine (TZ) for spasticity management and lidocaine (LD) for post-insertion pain relief. Reservoir-type implants were developed with TZ in the core and LD in the shell. Two fabrication methods—direct compression and vacuum compression moulding (VCM)—were evaluated for TZ-loaded pellets (3 mm diameter, ~10 mm length) using TZ base and TZ hydrochloride. Pellets were encapsulated inside a biodegradable polycaprolactone (PCL) tubular membrane to control drug release. Direct compression pellets, made with poly(vinyl pyrrolidone) and hydroxypropyl-β-cyclodextrin, disintegrated quickly, releasing TZ over 20 days. VCM pellets, formulated with PCL or PCL/poly(ethylene glycol) (PEG), offered prolonged release: up to 200 days for TZ base and 80 days for TZ hydrochloride. Adding PEG accelerated TZ release, reducing duration to 20 days (TZ base) and 125 days (TZ hydrochloride). LD was incorporated into the PCL membrane, providing up to three days of sustained release. Physicochemical analysis confirmed formulation homogeneity and no covalent interactions. These findings highlight the potential of this implant system for MS-related spasticity management, supporting further research into long-acting implants to improve treatment adherence and patient outcomes.
Solid Implantable Devices for Sustained Drug Delivery
(Elsevier, 2023) Magill, Elizabeth; Demartis, Sara; Gavini, Elisabetta; Permana, Andi Dian; Thakur, Raghu Raj Singh; Adrianto, Muhammad Faris; Waite, David; Glover, Katie; Picco, Camila J.; Korelidou, Anna; Domínguez Robles, Juan; Larrañeta, Eneko; Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica; Academy of Medical Sciences; Engineering and Physical Sciences Research Council (UK); European Union (UE). H2020; Ministerio de Ciencia e Innovación (MICIN). España
Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug administration routes. Oral and injectable drug administration are the most common routes for drug delivery providing peaks of drug concentrations in blood after administration followed by concentration decay after a few hours. Therefore, constant drug administration is required to keep drug levels within the therapeutic window of the drug. Moreover, oral drug delivery presents alternative challenges due to drug degradation within the gastrointestinal tract or first pass metabolism. IDDS can be used to provide sustained drug delivery for prolonged periods of time. The use of this type of systems is especially interesting for the treatment of chronic conditions where patient adherence to conventional treatments can be challenging. These systems are normally used for systemic drug delivery. However, IDDS can be used for localised administration to maximise the amount of drug delivered within the active site while reducing systemic exposure. This review will cover current applications of IDDS focusing on the materials used to prepare this type of systems and the main therapeutic areas of application.

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Examinando Farmacia y Tecnología Farmacéutica por Agencia financiadora "Engineering and Physical Sciences Research Council (UK)"