Farmacia y Tecnología Farmacéutica

URI permanente para esta comunidadhttps://hdl.handle.net/11441/11019

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Innovations in Cancer Therapy: Endogenous Stimuli-Responsive Liposomes as Advanced Nanocarriers
(MDPI, 2025-02-13) Torres, Jazmín; Valenzuela Oses, Johanna Karina; Rabasco Álvarez, Antonio María; González Rodríguez, María Luisa; García, Mónica Cristina; Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica; Agencia Nacional de Promoción Científica y Tecnológica. Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Argentina; Universidad de Córdoba. Argentina
Recent advancements in nanotechnology have revolutionized cancer therapy—one of the most pressing global health challenges and a leading cause of death—through the development of liposomes (L), lipid-based nanovesicles known for their biocompatibility and ability to encapsulate both hydrophilic and lipophilic drugs. More recent innovations have led to the creation of stimuli-responsive L that release their payloads in response to specific endogenous or exogenous triggers. Dual- and multi-responsive L, which react to multiple stimuli, offer even greater precision, improving therapeutic outcomes while reducing systemic toxicity. Additionally, these smart L can adjust their physicochemical properties and morphology to enable site-specific targeting and controlled drug release, enhancing treatment efficacy while minimizing adverse effects. This review explores the latest advancements in endogenous stimuli-responsive liposomal nanocarriers, as well as dual- and multi-responsive L that integrate internal and external triggers, with a focus on their design strategies, mechanisms, and applications in cancer therapy.

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Examinando Farmacia y Tecnología Farmacéutica por Agencia financiadora "Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Argentina"