idUS - Author profile: Tabares, Lucía

Por motivos de mantenimiento se ha deshabilitado el inicio de sesión temporalmente. Rogamos disculpen las molestias.

Name	Tabares, Lucía
Department	Fisiología Médica y Biofísica
Knowledge area	Fisiología
Professional category	Catedrática de Universidad
E-mail	Request

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Article SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models Franco Espín, Julio; Gatius, Alaó; Armengol, José Ángel; Arumugam, Saravanan; Moradi, Mehri; Sendtner, Michael; Calderó, Jordi; Tabares, Lucía (MDPI, 2022) muscular atrophy (SMA). SMN forms the core of a protein complex localized at the cytoplasm and nuclear gems and that ...
Article Editorial: Molecular Nanomachines of the Presynaptic Terminal, Volume II Tabares, Lucía; Rizzoli, Silvio O. (Frontiers Research Foundation, 2022) The synapse has been designed and refined during animal evolution for two main processes: (1) to translate and transmit ...
Article Functional regeneration of the murine neuromuscular synapse relies on long‑lasting morphological adaptations Bermedo García, Francisca; Zelada, Diego; Martínez, Esperanza; Tabares, Lucía; Henríquez, Juan Pablo (BMC, 2022) Background: In a broad variety of species, muscle contraction is controlled at the neuromuscular junction (NMJ), the ...
Article Presynaptic Mitochondria Communicate With Release Sites for Spatio-Temporal Regulation of Exocytosis at the Motor Nerve Terminal López Manzaneda, Mario; Fuentes Moliz, Andrea; Tabares, Lucía (Frontiers Research Foundation, 2022) Presynaptic Ca2+ regulation is critical for accurate neurotransmitter release, vesicle reloading of release sites, and ...
PhD Thesis Papel de la proteína de supervivencia de la motoneurona (SMN) en la maduración sináptica Franco Espín, Julio; Tabares, Lucía (2021) La atrofia muscular espinal (AME), la causa genética más frecuente de mortalidad infantil, es una enfermedad neurodegenerativa ...
Article Calcium is reduced in presynaptic mitochondria of motor nerve terminals during neurotransmission in SMA mice López Manzaneda, Mario; Franco Espín, Julio; Tejero Navarro, Rocío; Cano, Raquel; Tabares, Lucía (Oxford University Press, 2021) Spinal muscular atrophy (SMA) is an autosomal recessive degenerative motor neuron disease characterized by symmetrical ...
Article R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy Tejero, Rocío; Balk, Stefanie; Franco-Espin, Julio; Ojeda Orellana, Jorge; Hennlein, Luisa; Drexl, Hans; Tabares, Lucía; Jablonka, Sibylle; (Elsevier, 2020) Neurotransmission defects and motoneuron degeneration are hallmarks of spinal muscular atrophy, a monogenetic disease ...
Article The mouse levator auris longus muscle: an amenable model system to study the role of postsynaptic proteins to the maintenance and regeneration of the neuromuscular synapse Ojeda, Jorge; Bermedo-García, Francisca; Pérez, Viviana; Mella, Jessica; Hanna, Patricia; Herzberg, Daniel; Tejero, Rocío; López Manzaneda, Mario; Tabares, Lucía; Henríquez, Juan Pablo (Frontiers Media S.A., 2020) The neuromuscular junction (NMJ) is the peripheral synapse that controls the coordinated movement of many organisms. The ...
PhD Thesis Estudio del calcio mitocondrial en terminales nerviosos motores y su relación en el proceso de neurotransmisión. Alteraciones en la atrofia muscular espinal López Manzaneda, Mario; Tabares, Lucía (2019) La mitocondria es uno de los principales moduladores de los niveles de calcio citosólico además de la principal fuente de ...
Article BDNF is a mediator of glycolytic fiber-type specification in mouse skeletal muscle Delezie, Julien; Weihrauch, Martin; Maier, Geraldine; Tejero, Rocío; Ham, Daniel J.; Gill, Jonathan F.; Tabares, Lucía; Handschin, Christoph (NATL ACAD SCIENCES, 2019) Brain-derived neurotrophic factor (BDNF) influences the differentiation, plasticity, and survival of central neurons and ...
Article HERC1 Ubiquitin Ligase Is Required for Normal Axonal Myelination in the Peripheral Nervous System Bachiller, Sara; Roca Ceballos, María Angustias; García Domínguez, Irene; Pérez Villegas, Eva María; Martos Carmona, David; Pérez Castro, Miguel Ángel; Real Navarrete, Luis Miguel; Rosa, José Luis; Tabares, Lucía; Venero Recio, José Luis; Armengol, José Ángel; Carrión, Ángel Manuel; Ruiz Laza, Rocío (Springer, 2018) A missense mutation in HERC1 provokes loss of cerebellar Purkinje cells, tremor, and unstable gait in tambaleante (tbl) ...
Article Smn-Deficiency Increases the Intrinsic Excitability of Motoneurons Arumugam, Saravanan; Garcera, Ana; Soler, Rosa M.; Tabares, Lucía (2017) During development, motoneurons experience significant changes in their size and in the number and strength of connections ...
Article CSPα, a molecular co-chaperone essential for short and long-term synaptic maintenance López Ortega, Elena; Ruiz Laza, Rocío; Tabares, Lucía; (Frontiers Media S.A., 2017) Cysteine string protein a (CSPα) is a vesicle protein located in the presynaptic terminal of most synapses. CSPα is an ...
Article Carbonic anhydrase inhibitor acetazolamide shifts synaptic vesicle recycling to a fast mode at the mouse neuromuscular junction Bertone, Nicolas Ivan; Groisman, Ayelén Ivana; Mazzone, Graciela Lujan; Cano, Raquel; Tabares, Lucía; Uchitel, Osvaldo Daniel (Wiley, 2017) Acetazolamide (AZ), a molecule frequently used to treat different neurological syndromes, is an inhibitor of the carbonic ...
PhD Thesis Identificación de componentes moleculares sinápticos que contribuyen a la vulnerabilidad de los terminales nerviosos motores en un modelo múrido de atrofia muscular espinal Tejero Navarro, Rocío; Tabares, Lucía (2016) La Atrofia Muscular Espinal (AME), la causa genética más frecuente de mortalidad infantil, es una enfermedad neurodegenerativa ...
Article The Active and Periactive Zone Organization and the Functional Properties of Small and Large Synapses Cano, Raquel; Tabares, Lucía (2016) The arrival of an action potential (AP) at a synaptic terminal elicits highly synchronized quanta release. Repetitive APs ...
Article Editorial: Molecular nanomachines of the presynaptic terminal Rizzoli, Silvio O.; Tabares, Lucía (Frontiers Research Foundation, 2016)
Article Synaptotagmin-2, and -1, linked to neurotransmission impairment and vulnerability in Spinal Muscular Atrophy Tejero, Rocío; López Manzaneda, Mario; Arumugam, Saravanan; Tabares, Lucía (OXFORD UNIV PRESS, 2016) Spinal muscular atrophy (SMA) is the most frequent genetic cause of infant mortality. The disease is characterized ...
Article Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions Wu, Yuan Ju; Tejero, Rocío; Arancillo, Marife; Vardar, Gülcin; Korotkova, Tatiana; Kintscher, Michael; Tabares, Lucía; Rosenmund, Christian (AMER PHYSIOLOGICAL SOC, 2015) Syntaxin 1B is important for mouse postnatal survival and proper synaptic function at the mouse neuromuscular junctions. ...
Article Morphological and functional remodelling of the neuromuscular junction by skeletal muscle PGC-1 alpha Arnold, Anne Sophie; Gill, Jonathan; Christe, Martine; Ruiz Laza, Rocío; McGuirk, Shawn; St-Pierre, Julie; Tabares, Lucía; Handschin, Christoph (NATURE PUBLISHING GROUP, 2014) The neuromuscular junction (NMJ) exhibits high morphological and functional plasticity. In the mature muscle, the relative ...
PhD Thesis Different Modes of Synaptic Vesicle Recycling un Synaptophysin-pHluorin Transgenic Mouse Motor Nerve Terminals Cano García, Raquel; Tabares, Lucía (2014) In the present work, a new tool for studying synaptic vesicle exo- and end ... The adult vertebrate NMJ is a highly reliable ...
Article Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ Krieger, Frank; Elflein, Nicole; Ruiz Laza, Rocío; Guerra, Joana; Serrano, Antonio L.; Asan, Esther; Tabares, Lucía; Jablonka, Sibylle (Elsevier, 2013) Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a childhood motoneuron disease caused by mutations ...
Article Notch Signaling Pathway Is Activated in Motoneurons of Spinal Muscular Atrophy Lladó, Jerònia; Caraballo Miralles, Víctor; Tabares, Lucía; Torres Benito, Laura; Cardona Rossinyol, Andrea; Olmos, Gabriel; Garcera, Ana; Solar, Rosa María (2013)
PhD Thesis Función de la proteína de supervivencia de motoneuronas (SMN) en la maduración funcional y organización sináptica en un modelo murino de atrofia muscular espinal Torres Benito, Laura; Tabares, Lucía (2012) La Atrofia Muscular Espinal (AME) es una enfermedad autosómica recesiva caracterizada por debilidad muscular y deterioro ...
Article SMN Requirement for Synaptic Vesicle, Active Zone and Microtubule Postnatal Organization in Motor Nerve Terminals Torres Benito, Laura; Feodora Neher, Margret; Cano, Raquel; Tabares, Lucía (2011) Low levels of the Survival Motor Neuron (SMN) protein produce Spinal Muscular Atrophy (SMA), a severe monogenetic disease ...
Article Active zones and the readily releasable pool of synaptic vesicles at the neuromuscular junction of the mouse Ruiz Laza, Rocío; Cano, Raquel; Casañas, Juan José; Gaffield, Michael A.; Betz, William J.; Tabares, Lucía (SOC NEUROSCIENCE, 2011) Synchronous neurotransmitter releaseis a highly regulated processthattakes place at specializations atthe presynapticmembrane ...
Article Synaptic defects in spinal muscular atrophy animal models Torres-Benito, Laura; Ruiz Laza, Rocío; Tabares, Lucía (Wiley, 2011) Proximal spinal muscular atrophy, the most frequent genetic cause of childhood lethality, is caused by homozygous loss or ...
Article Multiple Functions of the Vesicular Proton Pump in Nerve Terminals Tabares, Lucía; Betz, Bill (Cell Press, 2010) Synaptic vesicles are acidified by a proton pump (vATPase), which allows vesicular uptake of neurotransmitters. After ...
Article Altered Intracellular Ca2+ Homeostasis in Nerve Terminals of Severe Spinal Muscular Atrophy Mice Ruiz Laza, Rocío; Casañas, Juan José; Torres-Benito, Laura; Cano, Raquel; Tabares, Lucía (SOC NEUROSCIENCE, 2010) Low levels of survival motor neuron (SMN) protein result in spinal muscular atrophy (SMA), a severe genetic disease ...
Article Ciliary neurotrophic factor-induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy Simon, Christian M.; Jablonka, Sibylle; Ruiz Laza, Rocío; Tabares, Lucía; Sendtner, Michael (OXFORD UNIV PRESS, 2010) Proximal spinal muscular atrophy (SMA) is caused by homozygous loss or mutation of the SMN1 gene on human chromosome 5. ...
PhD Thesis Monitorización de la función sináptica normal y patológica en modelos animales Ruiz Laza, Rocío; Tabares, Lucía (2009) El objetivo principal de esta Tesis Doctoral ha sido el estudio de la transmisión sináptica en la unión neuromuscular. El ...
Article The spatial pattern of exocytosis and post-exocytic mobility of synaptopHluorin in mouse motor nerve terminals Gaffield, Michael A.; Tabares, Lucía; Betz, William J. (Wiley, 2009) We monitored the spatial distribution of exo- and endocytosis at 37◦C in mouse motor nerve terminals expressing synaptopHluorin ...
Article Preferred Sites of Exocytosis and Endocytosis Colocalize during High- But Not Lower-Frequency Stimulation in Mouse Motor Nerve Terminals Gaffield, Michael A.; Tabares, Lucía; Betz, William J. (SOC NEUROSCIENCE, 2009) The spatial relationship of exocytosis and endocytosis in motor nerve terminals has been explored, with varied results, ...
Article Cysteine string protein-α is essential for the high calciumsensitivity of exocytosis in a vertebrate synapse Ruiz Laza, Rocío; Casañas, J. J.; Südhof, T. C.; Tabares, Lucía (Wiley, 2008) Cysteine string protein (CSPa) is a synaptic vesicle protein present in most central and peripheral nervous system ...
Article Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration Cabanes, Carmen; Bonilla, Sonia; Tabares, Lucía; Martínez, Salvador (2007) Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration of motoneurons. ...
Article Neuroprotective effect of adult hematopoietic stem cells in a mouse model of motoneuron degeneration Cabanes, Carmen; Bonilla, Sonia; Tabares, Lucía; Martínez, Salvador (2007) Degenerative spinal motor diseases, like amyotrophic lateral sclerosis, are produced by progressive degeneration of ...
Article Monitoring synaptic function at the neuromuscular junction of a mouse expressing synaptopHluorin Tabares, Lucía; Ruiz Laza, Rocío; Linares Clemente, Pedro; Gaffield, Michael A.; Álvarez de Toledo Naranjo, Guillermo; Fernández-Chacón, Rafael; Betz, William J. (2007) We monitored presynaptic exocytosis and vesicle recycling at neuromuscular junctions of transgenic mice expressing ...
Article CSP alpha-deficiency causes massive and rapid photoreceptor degeneration Schmitz, Frank; Tabares, Lucía; Khimich, Darina; Strenzke, Nicola; Villa Polo, Pedro de la; Castellano Muñoz, Manuel; Bulankina, Anna; Moser, Tobias; Fernández-Chacón, Rafael; Südhof, Thomas C. (2006) Cysteine string protein (CSP) _ is an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of ...
Article Treatment with trkC agonist antibodies delays disease progression in neuromuscular degeneration (nmd) mice Ruiz Laza, Rocío; Lin, J.; Forgie, A.; Foletti, D.; Shelton, D.; Rosenthal, A.; Tabares, Lucía (OXFORD UNIV PRESS, 2005) Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal autosomal recessive disorder seen in infants. ...
Article The synaptic vesicle protein CSP alpha prevents presynaptic degeneration Fernández-Chacón, Rafael; Wolfel, M.; Nishimune, H.; Tabares, Lucía; Schmitz, Frank; Castellano-Munoz, M.; Rosenmund, Christian; Montesinos Gutiérrez, María Luz; Sudhof, TC (CELL PRESS, 2004) Cysteine string protein α (CSPα)—an abundant synaptic vesicle protein that contains a DNA-J domain characteristic of Hsp40 ...
Article Exocytosis of catecholamine (CA)-containing and CA-free granules in chromaffin cells Tabares, Lucía; Alés González de la Higuera, Eva María; Lindau, Manfred; Álvarez de Toledo Naranjo, Guillermo (Science Direct, 2001) Recent evidence suggests that endocytosis in neuroendocrine cells and neurons can be tightly coupled to exocytosis, allowing ...
Article Dopamine induces intracellular Ca2+ signals mediated by alpha(1B)-adrenoceptors in rat pineal cells Rey, Elkin; Hernández-Díaz, Francisco J.; Abreu, Pedro; Alonso, Rafael; Tabares, Lucía (ELSEVIER SCIENCE BV, 2001) We have studied the functional interaction of dopamine with a -adrenoceptor subtypes by measuring intracellular Ca2q 1 ...
PhD Thesis Incremento de la concentración de calcio intracelular inducida por dopamina en celulas pineales de rata Rey Gaitán, Carlos Elkin; Tabares, Lucía (1999)
PhD Thesis Estudio de la señal de calcio y las corrientes iónicas en el acoplamiento entre el estímulo y la secreción en células pineales en la rata Marín Caballos, Antonio Jesús; Tabares, Lucía (1995) Se han empleado distintas técnicas para estudiar los mecanismos implicados en las diferentes etapas del proceso de ...
Article Properties of Calcium and Potassium Currents of Clonal Adrenocortical Cells López Barneo, José; Tabares, Lucía; Ureña López, Juan (1989) The ionic currents of clonal Y-1 adrenocortical cells were studied using the whole-cell variant of the patch-clamp technique. ...
Article Effects of membrane depolarization and divalent-cations on anaphylactic histamine secretion Pintado, E.; Dorado, M.E.; Tabares, Lucía; López Barneo, José (1986) The effects of membrane depolariz.ation and divalent cations on histamine release have been studied in sensitized mast ...
PhD Thesis Electrofisiología de células adrenocorticales: Estudio mediante el registro intracelular y la técnica de “patch clamp” Tabares, Lucía; López Barneo, José (1985) El presente trabajo se centra en el estudio de las características electrofisiológicas de células adrenocorticales en ...

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