Author profile: Pastor Loro, Ángel Manuel
Institutional data
Name | Pastor Loro, Ángel Manuel |
Department | Fisiología |
Knowledge area | Fisiología |
Professional category | Catedrático de Universidad |
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Statistics
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No. publications
60
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No. visits
7051
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No. downloads
8899
Publications |
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Article
The Gap Junction Inhibitor Octanol Decreases Proliferation and Increases Glial Differentiation of Postnatal Neural Progenitor Cells
(Multidisciplinary Digital Publishing Institute (MDPI), 2024)
Neural precursor cells (NPCs) that persist in the postnatal/adult subventricular zone (SVZ) express connexins that form ... |
Article
VEGF expression disparities in brainstem motor neurons of the SOD1GP3A ALS model: Correlations with neuronal vulnerability
(Elsevier, 2024)
Amyotrophic lateral sclerosis (ALS) is a rare neuromuscular disease characterized by severe muscle weakness mainly due to ... |
Article
Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells
(Frontiers Media, 2023)
The subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which ... |
Article
Role of Vascular Endothelial Growth Factor as a Critical Neurotrophic Factor for the Survival and Physiology of Motoneurons
(Wolters Kluwer Health, 2023)
Vascular endothelial growth factor (VEGF) was discovered by its angiogenic activity. However, during evolution, it appeared ... |
Article
Preservation of KCC2 expression in axotomized abducens motoneurons and its enhancement by VEGF
(Springer Nature, 2023)
The potassium chloride cotransporter 2 (KCC2) is the main Cl− extruder in neurons. Any alteration in KCC2 levels leads to ... |
Article
Relative contribution of lateral vestibular neuron and abducens internuclear neuron inputs to the discharge activity of medial rectus motoneurons
(Springer, 2023)
Medial rectus motoneurons mediate nasally directed horizontal eye movements. These motoneurons receive two major excitatory ... |
Article
Proprioceptors in extraocular muscles
(Wiley-Blackwell, 2023)
New Findings: What is the topic of this review? This review aims to evaluate the literature on proprioceptors and particular ... |
Article
BDNF Influence on Adult Terminal Axon Sprouting after Partial Deafferentation
(Multidisciplinary Digital Publishing Institute (MDPI), 2023)
BDNF is a neurotrophin family member implicated in many different neuronal functions, from neuronal survival during ... |
Article
VEGF and Neuronal Survival
(SAGE, 2022)
Vascular endothelial growth factor (VEGF) is well known for its angiogenic activity, but recent evidence has revealed a ... |
Article
Spinal cord from body donors is suitable for multicolor immunofluorescence
(Springer Nature, 2022)
Immunohistochemistry is a powerful tool for studying neuronal tissue from humans at the molecular level. Obtaining fresh ... |
Article
Eye Movements But Not Vision Drive the Development of Palisade Endings
(Association for Research in Vision and Ophthalmology, 2022)
PURPOSE. To test whether visual experience and/or eye movements drive the postnatal development of palisade endings in ... |
Article
VEGF is an essential retrograde trophic factor for motoneurons
(National Academy of Sciences, 2022)
VEGF was initially discovered due to its angiogenic activity and therefore named "vascular endothelial growth factor."However, ... |
PhD Thesis
Estrategias reparativas en el sistema oculomotor tras la lesión mediante la administración del factor de crecimiento del endotelio vascular (VEGF)
(2021)
El factor de crecimiento del endotelio vascular (VEGF) es una proteína englobada en la familia de los factores tróficos. ... |
Article
MIF versus SIF motoneurons, what are their respective contribution in the oculomotor medial rectus pool?
(Society for Neuroscience, 2021)
Multiply-innervated muscle fibers (MIFs) are peculiar to the extraocular muscles as they are non-twitch but produce a slow ... |
Article
Neuroprotective Effect of Vascular Endothelial Growth Factor on Motoneurons of the Oculomotor System
(MDPI, 2021)
Vascular endothelial growth factor (VEGF) was initially characterized as a potent angiogenic factor based on its activity ... |
Article
Purinergic Receptor Blockade with Suramin Increases Survival of Postnatal Neural Progenitor Cells In Vitro
(MDPI, 2021)
Neural progenitor cells (NPCs) are self-renewing and multipotent cells that persist in the postnatal and adult brain in ... |
Article
Sources and lesion-induced changes of VEGF expression in brainstem motoneurons
(Springer Nature, 2020)
Motoneurons of the oculomotor system show lesser vulnerability to neurodegeneration compared to other cranial motoneurons, ... |
Article
Muscle Progenitors Derived from Extraocular Muscles Express Higher Levels of Neurotrophins and their Receptors than other Cranial and Limb Muscles
(MDPI, 2020)
Extraocular muscles (EOMs) show resistance to muscle dystrophies and sarcopenia. It has been recently demonstrated that ... |
Article
A Single Intraventricular Injection of VEGF Leads to Long-Term Neurotrophic Effects in Axotomized Motoneurons
(Society for Neuroscience, 2020)
Vascular endothelial growth factor (VEGF) has been recently demonstrated to induce neuroprotective and synaptotrophic ... |
Article
Structural and molecular characteristics of axons in the long head of the biceps tendon
(Springer Nature, 2020)
The innervation of the long head of the biceps tendon (LHBT) is not sufficiently documented. This is a drawback since ... |
Article
Palisade endings have an exocytotic machinery but lack acetylcholine receptors and distinct acetylcholinesterase activity
(ARVO, 2020)
Purpose: The purpose of this work was to test whether palisade endings express structural and molecular features of ... |
Patent. Invention
Procedimiento para prolongar la vida media de células progenitoras neurales neonatales con suramina
(Oficina Española de Patentes y Marcas , 2019)
Uso de la suramina para prolongar la vida media de células progenitoras neurales neonatales.La presente invención se refiere ... |
Article
Functional diversity of motoneurons in the oculomotor system
(National Academy of Sciences, 2019)
Extraocular muscles contain two types of muscle fibers according to their innervation pattern: singly innervated muscle ... |
Article
Extracellular Vesicle-Mediated Communication between the Glioblastoma and Its Microenvironment
(MDPI, 2019)
The glioblastoma is the most malignant form of brain cancer. Glioblastoma cells use multiple ways of communication with ... |
Article
Short-term plasticity after partial deafferentation in the oculomotor system
(Springer Nature, 2019)
Medial rectus motoneurons are innervated by two main pontine inputs. The specific function of each of these two inputs ... |
Article
Neural Stem Cells of the Subventricular Zone as the Origin of Human Glioblastoma Stem Cells. Therapeutic Implications
(Frontiers Media, 2019)
Human glioblastoma is the most aggressive type of primary malignant brain tumors. Standard treatment includes surgical ... |
PhD Thesis
Dependencias tróficas y sinápticas del sistema oculomotor.
(2018)
Las motoneuronas del recto medial presentes en el núcleo motor ocular común (NMOC) reciben dos entradas pontinas principales: ... |
Article
Vascular Endothelial Growth Factor (VEGF) Prevents the Downregulation of the Cholinergic Phenotype in Axotomized Motoneurons of the Adult Rat
(Frontiers Media, 2018)
Vascular endothelial growth factor (VEGF) was initially characterized by its activity on the vascular system. However, ... |
Article
Effects of Selective Deafferentation on the Discharge Characteristics of Medial Rectus Motoneurons
(Society for Neuroscience, 2018)
Medial rectus motoneurons receive two main pontine inputs: abducens internuclear neurons, whose axons course through the ... |
Article
Vascular endothelial growth factor: an essential neurotrophic factor for motoneurons?
(Medknow Publications, 2018)
|
Article
Synaptic loss and firing alterations in Axotomized Motoneurons are restored by vascular endothelial growth factor (VEGF) and VEGF-B
(Elsevier, 2018)
Vascular endothelial growth factor (VEGF), also known as VEGF-A, was discovered due to its vasculogenic and angiogenic ... |
Article
Interactions between neural progenitor cells and microglia in the subventricular zone: physiological implications in the neurogenic niche and after implantation in the injured brain
(Frontiers Media, 2018)
The adult subventricular zone (SVZ) of the mammalian brain contains neural progenitor cells (NPCs) that continuously produce ... |
Article
Extraocular motoneurons of the adult rat show higher levels of vascular endothelial growth factor and its receptor Flk-1 than other cranial motoneurons
(Public Library of Science, 2017)
Recent studies show a relationship between the deficit of vascular endothelial growth factor (VEGF) and motoneuronal ... |
Article
Palisade endings of extraocular muscles develop postnatally following different time courses
(Association for Research in Vision and Ophthalmology, 2017)
PURPOSE. To analyze in a frontal-eyed mammal (cat) the postnatal development of palisade endings in extraocular muscles ... |
Article
Extraocular Motor System Exhibits a Higher Expression of Neurotrophins When Compared with Other Brainstem Motor Systems
(Frontiers Media, 2017)
Extraocular motoneurons resist degeneration in diseases such as amyotrophic lateral sclerosis. The main objective of the ... |
Article
Functional Diversity of Neurotrophin Actions on the Oculomotor System
(MDPI AG, 2016)
Neurotrophins play a principal role in neuronal survival and differentiation during development, but also in the maintenance ... |
Article
Palisade Endings Are a Constant Feature in the Extraocular Muscles of Frontal-Eyed, But Not Lateral-Eyed, Animals
(Association for Research in Vision and Ophthalmology, 2016)
Purpose To test whether palisade endings are a general feature of mammalian extraocular muscles (EOMs). Methods Thirteen ... |
PhD Thesis
Implante de progenitores neurales en un modelo de lesión del sistema oculomotor
(2015)
El implante de células progenitoras neurales en el sistema nervioso central lesionado es una poderosa herramienta reparadora. ... |
PhD Thesis
Reacción glial tras el implante de precursores neurales en un modelo de lesión del sistema nervioso central
(2015)
En el cerebro adulto existen dos regiones con capacidad neurogénica, el giro dentado del hipocampo y la zona subventricular ... |
Article
Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells
(Frontiers Research Foundation, 2015)
The postnatal subventricular zone (SVZ) lining the walls of the lateral ventricles contains neural progenitor cells (NPCs) ... |
Article
Neural Progenitor Cell Implants in the Lesioned Medial Longitudinal Fascicle of Adult Cats Regulate Synaptic Composition and Firing Properties of Abducens Internuclear Neurons
(Society for Neuroscience, 2014)
Transplants of neural progenitor cells (NPCs) into the injured CNS have been proposed as a powerful tool for brain repair, ... |
Article
Implanted neural progenitor cells regulate glial reaction to brain injury and establish gap junctions with host glial cells
(Wiley-Blackwell, 2014)
Transplantation of neural stem/progenitor cells (NPCs) in the lesioned brain is able to restore morphological and physiological ... |
Article |
Article
Axons Giving Rise to the Palisade Endings of Feline Extraocular Muscles Display Motor Features
(Society for Neuroscience, 2013)
Palisade endings are nerve specializations found in the extraocular muscles (EOMs) of mammals, including primates. They ... |
Article
PSA-NCAM is expressed in immature, but not recently generated, neurons in the adult cat cerebral cortex layer II
(Frontiers Media S.A., 2011)
Neuronal production persists during adulthood in the dentate gyrus and the olfactory bulb, where substantial numbers of ... |
Article
Evidence that the extraocular motor nuclei innervate monkey palisade endings
(Elsevier, 2011)
Palisade endings are found in the extraocular muscles (EOMs) of almost every mammalian species, including primates. These ... |
Article
Dual encoding of muscle tension and eye position by abducens motoneurons
(Society for Neuroscience, 2011)
Extraocular muscle tension associated with spontaneous eye movements has a pulse-slide-step profile similar to that of ... |
Article
Differential regulation of the expression of neurotrophin receptors in rat extraocular motoneurons after lesion
(Wiley, 2011)
Neurotrophins acting through high-affinity tyrosine kinase receptors (trkA, trkB, and trkC) play a crucial role in regulating ... |
Article
The Use of PRV-Bartha to Define Premotor Inputs to Lumbar Motoneurons in the Neonatal Spinal Cord of the Mouse
(Public Library of Science, 2010)
Background The neonatal mouse has become a model system for studying the locomotor function of the lumbar spinal cord. ... |
Article
Nerve Growth Factor Regulates the Firing Patterns and Synaptic Composition of Motoneurons
(Society for Neuroscience, 2010)
Target-derived neurotrophins exert powerful synaptotrophic actions in the adult brain and are involved in the regulation ... |
PhD Thesis
Regulación neurotrófica de las propiedades de disparo y de la sinaptología aferente sobre las motoneuronas axotomizadas del núcleo motor ocular externo
(2010)
La teoría trófica de las conexiones neuronales establece que durante el desarrollo embrionario los órganos diana son ... |
Article
Complementary Actions of BDNF and Neurotrophin-3 on the Firing Patterns and Synaptic Composition of Motoneurons
(Society for Neuroscience, 2009)
Neurotrophins, as target-derived factors, are essential for neuronal survival during development, but during adulthood, ... |
Patent. Invention
Dispositivo para la administración de sustancias, estimulación y registro daser
(Oficina Española de Patentes y Marcas (OEPM), 2007)
Dispositivo para la administración de sustancias, estimulación y registro daser. Se trata de un dispositivo para uso ... |
Article
Regulation of Gephyrin Cluster Size and Inhibitory Synaptic Currents on Renshaw Cells by Motor Axon Excitatory Inputs
(Society for Neuroscience, 2005)
Renshaw cells receive a high density of inhibitory synapses characterized by large postsynaptic gephyrin clusters and mixed ... |
Patent. Invention
Electrodo de succión flotante.
(Oficina Española de Patentes y Marcas , 2004)
Electrodo de succión flotante.Se trata de un dispositivo de registro neurofisiológico que permite la monitorización eléctrica ... |
PhD Thesis
Efectos de la reinervación de una nueva diana por neuronas centrales axotomizadas
(2004)
Se realizó un estudio de los efectos de un implante de primordio cerebeloso como posible nueva diana para las neuronas ... |
Article |
Patent. Invention
Discriminador de formas de potenciales de acción
(Oficina Española de Patentes y Marcas (OEPM), 1998)
Discriminador de formas de potenciales de acción, que permite seleccionar, dentro de un tren de potenciales de acción o ... |
Patent. Invention
Sistema de adquisición de datos ininterrumpido en tiempo real
(Oficina Española de Patentes y Marcas (OEPM), 1997)
Sistema de adquisición de datos ininterrumpido en tiempo real, que permite la monitorización y el almacenamiento en memoria ... |
Article
Eye position and eye velocity integrators reside in separate brainstem nuclei.
(National Academy of Sciences, 1994)
Two types of central nervous system integrators are critical for oculomotor performance. The first integrates velocity ... |