Perfil del autor: Lucas Rodríguez, Ricardo
Datos institucionales
Nombre | Lucas Rodríguez, Ricardo |
Departamento | Química Orgánica y Farmaceútica |
Área de conocimiento | Química Orgánica |
Categoría profesional | Profesor Titular de Universidad |
Correo electrónico | Solicitar |
Estadísticas
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Nº publicaciones
30
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Nº visitas
4143
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Nº descargas
3946
Publicaciones |
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Artículo
Simultaneous Formation of Polyhydroxyurethanes and Multicomponent Semi-IPN Hydrogels
(MDPI, 2024)
This study introduces an efficient strategy for synthesizing polyhydroxyurethane-based multicomponent hydrogels with ... |
Artículo
Synthesis and Antimicrobial Activity of Aminoalkyl Resveratrol Derivatives Inspired by Cationic Peptides
(Taylor & Francis, 2023)
Antimicrobial resistance is a global concern, far from being resolved. The need of new drugs against new targets is imminent. ... |
Artículo
Chemically Tuning Resveratrol for the Effective Killing of Gram- Positive Pathogens
(ACS, 2022)
In the era of antimicrobial resistance, the identification of new compounds with strong antimicrobial activity and the ... |
Artículo
Neuroprotective and Anti-inflammatory Effects of Pterostilbene Metabolites in Human Neuroblastoma SH-SY5Y and RAW 264.7 Macrophage Cells
(American Chemical Society, 2020)
Oxidative stress is known to be a key factor in many neurodegenerative diseases. Inflammation also plays a relevant role ... |
Artículo
In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations
(MDPI, 2020)
The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. ... |
Trabajo Fin de Grado
El fútbol como medio para la inclusión social en Educación Primaria
(2020)
Para este trabajo de Fin de Grado se ha realizado un estudio sobre el deporte, más concretamente, sobre la inclusión ... |
Artículo
Nanostructured Chitosan-Based Biomaterials for Sustained and Colon-Specific Resveratrol Release
(MDPI, 2019)
In the present work, we demonstrate the preparation of chitosan-based composites as vehicles of the natural occurring ... |
Artículo
Validation of Smart Nanoparticles as Controlled Drug Delivery Systems: Loading and pH-Dependent Release of Pilocarpine
(American Chemical Society, 2018)
Micelles are good devices for use as controlled drug delivery systems because they exhibit the ability to protect the ... |
Trabajo Fin de Grado
¿Está presente la diversidad familiar en el aula?
(2018)
El siguiente trabajo de fin de grado pretende la visión, tanto de docentes como del alumnado, del tercer ciclo de Educación ... |
Artículo
Glucose-nucleobase pairs within DNA: Impact of hydrophobicity, alternative linking unit and DNA polymerase nucleotide insertion studies
(Royal Society of Chemistry, 2018)
Recently, we studied glucose-nucleobase pairs, a binding motif found in aminoglycoside-RNA recognition. DNA duplexes with ... |
Artículo
pH-Responsive Polymeric Nanoparticles as Drug Delivery Systems
(JSciMed Central, 2017)
Micelles are excellent devices to be used as controlled drug delivery systems since they exhibit the ability to protect ... |
Artículo
Effect of metabolites of hydroxytyrosol on protection against oxidative stress and inflammation in human endothelial cells
(Elsevier, 2017)
The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative ... |
Artículo
Tyrosol and its metabolites as antioxidative and anti-inflammatory molecules in human endothelial cells
(Royal Society of Chemistry, 2017)
Tyrosol (Tyr) is a phenolic compound found in virgin olive oil. After ingestion, Tyr undergoes extensive first pass ... |
Artículo
Tyrosol and hydroxytyrosol derivatives as antitrypanosomal and antileishmanial agents
(Elsevier, 2016)
Trypanosomiasis and leishmaniasis keep being a real challenge for health and development of African countries. Existing ... |
Artículo
Cytotoxic, Antiangiogenic and Antitelomerase Activity of Glucosyl- and Acyl- Resveratrol Prodrugs and Resveratrol Sulfate Metabolites
(Wiley-Blackwell, 2016)
Resveratrol (RES) is a natural polyphenol with relevant and varied biological activity. However, its low bioavailability ... |
Artículo
Hydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cells
(Royal Society of Chemistry, 2016)
The aim of this study was to investigate the ability of the sulfate metabolites of hydroxytyrosol (HT) and tyrosol (TYR) ... |
Artículo
Glucose–Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA
(Wiley-Blackwell, 2016)
Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside–RNA ... |
Artículo
Antioxidant activity of alkyl gallates and glycosyl alkyl gallates in fish oil in water emulsions: Relevance of their surface active properties and of the type of emulsifier
(Elsevier, 2015)
The antioxidant activity of gallic acid and a series of alkyl gallates (C4-C18) and glycosylated alkyl gallates (C4-C18) ... |
Artículo
Effects of Sugar Functional Groups, Hydrophobicity, and Fluorination on Carbohydrate–DNA Stacking Interactions in Water
(American Chemical Society, 2014)
Carbohydrate–aromatic interactions are highly relevant for many biological processes. Nevertheless, experimental data in ... |
Artículo
Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End
(Wiley-Blackwell, 2013)
Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, ... |
Artículo
The Gut Microbiota Ellagic Acid-Derived Metabolite Urolithin A and Its Sulfate Conjugate Are Substrates for the Drug Efflux Transporter Breast Cancer Resistance Protein (ABCG2/BCRP)
(American Chemical Society, 2013)
The breast cancer resistance protein (BCRP/ABCG2) is a drug efflux transporter that can affect the pharmacological and ... |
Artículo
Synthesis, RNAi activity and nuclease-resistant properties of apolar carbohydrates siRNA conjugates
(Elsevier, 2013)
Oligoribonucleotide conjugates carrying apolar carbohydrates at the 5′-end and the corresponding siRNA duplexes have been ... |
Artículo
Apolar carbohydrates as DNA capping agents
(Royal Society of Chemistry, 2012)
Mono- and disaccharides have been shown to stack on top of DNA duplexes stabilizing sequences with terminal C–G base pairs. ... |
Artículo
Resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives reduce Escherichia coli O157:H7, Salmonella typhimurium, and Listeria monocytogenes Scott A adhesion to colonic epithelial cell lines
(American Chemical Society, 2012)
The efficacy of resveratrol and some glucosyl, glucosylacyl, and glucuronide derivatives in inhibiting the adhesion of ... |
Artículo
Metabolites and tissue distribution of resveratrol in the pig
(Wiley-Blackwell, 2011)
Scope: trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism ... |
Artículo
Highly Polar Carbohydrates Stack Onto DNA Duplexes Via CH/π Interactions
(American Chemical Society, 2011)
Carbohydrate-nucleic acid contacts are known to be a fundamental part of some drug-DNA recognition processes. Most of these ... |
Artículo
Synthesis and in vitro inhibition properties of siRNA conjugates carrying glucose and galactose with different presentations
(Springer Nature, 2011)
Oligoribonucleotide conjugates and the corresponding siRNA duplexes against tumor necrosis factor carrying one, two, or ... |
Artículo
Preventive oral treatment with resveratrol pro-prodrugs drastically reduce colon inflammation in rodents
(American Chemical Society, 2010)
There is no pharmaceutical or definitive surgical cure for inflammatory bowel diseases (IBDs). The naturally occurring ... |
Artículo
Synthesis, cell-surface binding, and cellular uptake of fluorescently labeled glucose-DNA conjugates with different carbohydrate presentation
(American Chemical Society, 2010)
Oligonucleotide conjugates carrying carbohydrates at the 5′-end have been prepared. Glucose, fucose, and saccharides ... |
Artículo
Surface-Active Properties of Lipophilic AntioxidantsTyrosol and Hydroxytyrosol Fatty Acid Esters: A PotentialExplanation for the Nonlinear Hypothesis of the AntioxidantActivity in Oil-in-Water Emulsions
(American Chemical Society, 2001)
Our group has recently observed a nonlinear tendency in antioxidant capacity of different hydroxytyrosol fatty acid esters ... |