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Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications

 

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Opened Access Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications
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Author: Contardi, M.
Alfaro-Pulido, A.
Picone, P.
Guzmán-Puyol, S.
Goldoni, L.
Benítez Jiménez, José Jesús
Heredia, Antonio
Bathel, M. J.
Department: Instituto de Ciencia de Materiales de Sevilla (ICMS) – CIC Cartuja
Date: 2019-04
Published in: Plos One, 14 (4), e0214956-1-e0214956-18.
Document type: Article
Abstract: ϵ-caprolactone-p-coumaric acid copolymers at different mole ratios (ϵ-caprolactone:p-coumaric acid 1:0, 10:1, 8:1, 6:1, 4:1, and 2:1) were synthesized by melt-polycondensation and using 4-dodecylbenzene sulfonic acid as catalyst. Chemical analysis by NMR and GPC showed that copolyesters were formed with decreasing molecular weight as p-coumaric acid content was increased. Physical characteristics, such as thermal and mechanical properties, as well as water uptake and water permeability, depended on the mole fraction of pcoumaric acid. The p-coumarate repetitive units increased the antioxidant capacity of the copolymers, showing antibacterial activity against the common pathogen Escherichia coli. In addition, all the synthesized copolyesters, except the one with the highest concentration of the phenolic acid, were cytocompatible and hemocompatible, thus becoming potentially useful for skin regeneration applications.
Cite: Contardi, M., Alfaro-Pulido, A., Picone, P., Guzmán-Puyol, S., Goldoni, L., Benítez Jiménez, J.J.,...,Bathel, M.J. (2019). Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications. Plos One, 14 (4), e0214956-1-e0214956-18.
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URI: https://hdl.handle.net/11441/88457

DOI: 10.1371/journal.pone.0214956

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