dc.creator | Sayagués de Vega, María Jesús | es |
dc.creator | Ríos de la Rosa, Julio | es |
dc.creator | Oliva, José María | es |
dc.creator | Sánchez Alcázar, José Antonio | es |
dc.creator | Merkling, Patrick J. | es |
dc.date.accessioned | 2018-05-14T08:42:08Z | |
dc.date.available | 2018-05-14T08:42:08Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Sayagués de Vega, M.J., Ríos de la Rosa, J., Oliva, J.M., Sánchez Alcázar, J.A. y Merkling, P.J. (2018). Solvent-assisted in situ synthesis of cysteamine-capped silver nanoparticles. Advances in Natural Sciences: Nanoscience and Nanotechnology, 9, 1-10. | |
dc.identifier.issn | 2043-6262 | es |
dc.identifier.uri | https://hdl.handle.net/11441/74556 | |
dc.description.abstract | Silver nanoparticles offer a huge potential for biomedical applications owing to their exceptional
properties and small size. Specifically, cysteamine-capped silver nanoparticles could form the
basis for new anticancer therapies combining the cytotoxic effect of the silver core with the
inherent antitumor activity of cysteamine, which inhibit cancer cell proliferation and suppress
invasion and metastasis. In addition, the capability of the cysteamine coating monolayer to
couple a variety of active principles and targeting (bio)molecules of interest proves key to
the tailoring of this platform in order to exploit the pathophysiology of specific tumor types.
Nevertheless, the chain length and conformational flexibility of cysteamine, together with its
ability to attach to the surface of silver nanoparticles via both the thiol and the amine group, have
made the in situ synthesis of these particles an especially challenging task. Herein we report a
solvent-assisted in situ synthesis method that solves this problem. The obtained nanoparticles
have been fully characterized by UV–visible absorption spectroscopy, Fourier transform
infrared spectroscopy, transmission electron microscopy, electron diffraction measurement, high
resolution transmission electron microscopy, scanning transmission electron microscopy, energy
dispersive x-ray spectroscopy nanoanalysis, and dynamic light scattering measurement. Our
synthesis method achieves extremely high yield and surface coating ratio, and colloidal stability
over a wide range of pH values including physiological pH. Additionally, we have demonstrated
that cysteamine-capped nanoparticles obtained by this method can be conjugated to an antibody
for active targeting of the epidermal growth factor receptor, which plays an important role in
the pathogenesis and progression of a wide variety of tumors, and induce cell death in human
squamous carcinoma cells. We believe this method can be readily extended to combinations of
noble metals and longer chain primary, secondary, ternary or even quaternary aminethiols | es |
dc.description.sponsorship | España, Junta de Andalucía P10- FQM-6615 | es |
dc.description.sponsorship | España, Ministerio de Economia y Competitividad CTP2016-80206-P | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | IOP Publishing | es |
dc.relation.ispartof | Advances in Natural Sciences: Nanoscience and Nanotechnology, 9, 1-10. | |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cysteamine | es |
dc.subject | 2-mercaptoethylamine | es |
dc.subject | Silver nanoparticles | es |
dc.subject | DMF | es |
dc.subject | Targeted antitumor therapy | es |
dc.subject | Epidermal growth factor receptor | es |
dc.title | Solvent-assisted in situ synthesis of cysteamine-capped silver nanoparticles | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.relation.projectID | CTP2016-80206-P | es |
dc.relation.projectID | P10- FQM-6615 | es |
dc.relation.publisherversion | https://doi.org/10.1088/2043-6254/aa9de9 | es |
dc.identifier.doi | 10.1088/2043-6254/aa9de9 | es |
idus.format.extent | 10 p. | es |
dc.journaltitle | Advances in Natural Sciences: Nanoscience and Nanotechnology | es |
dc.publication.volumen | 9 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 10 | es |
dc.contributor.funder | Junta de Andalucía | |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | |