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Novel features of telomere biology revealed by the absence of telomeric DNA methylation

Opened Access Novel features of telomere biology revealed by the absence of telomeric DNA methylation

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Autor: Vega Vaquero, Alejandro
Bonoro, Giancarlo
Morselli, Marco
Vaquero Sedas, María Isabel
Rubbi, Liudmilla
Pellegrini, M.
Vega Palas, Miguel Ángel
Departamento: Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular
Fecha: 2016
Publicado en: Genome Research, 26, 1047-1056.
Tipo de documento: Artículo
Resumen: Cytosine methylation regulates the length and stability of telomeres, which can affect a wide variety of biological features, including cell differentiation, development, or illness. Although it is well established that subtelomeric regions are methylated, the presence of methylated cytosines at telomeres has remained controversial. Here, we have analyzed multiple bisulfite sequencing studies to address the methylation status of Arabidopsis thaliana telomeres. We found that the levels of estimated telomeric DNA methylation varied among studies. Interestingly, we estimated higher levels of telomeric DNA methylation in studies that produced C-rich telomeric strands with lower efficiency. However, these high methylation estimates arose due to experimental limitations of the bisulfite technique. We found a similar phenomenon for mitochondrial DNA: The levels of mitochondrial DNA methylation detected were higher in experiments with lower mitochondrial read production effici...
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Cita: Vega Vaquero, A., Bonoro, G., Morselli, M., Vaquero Sedas, M.I., Rubbi, L., Pellegrini, M. y Vega Palas, M.Á. (2016). Novel features of telomere biology revealed by the absence of telomeric DNA methylation. Genome Research, 26, 1047-1056.
Tamaño: 1.717Mb
Formato: PDF

URI: http://hdl.handle.net/11441/68550

DOI: 10.1101/gr.202465.115

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