dc.creator | Romero Campero, Francisco José | es |
dc.creator | Pérez Jiménez, Mario de Jesús | es |
dc.date.accessioned | 2017-12-26T08:40:45Z | |
dc.date.available | 2017-12-26T08:40:45Z | |
dc.date.issued | 2008 | |
dc.identifier.citation | Romero Campero, F.J. y Pérez Jiménez, M.d.J. (2008). Modelling gene expression control using P systems: The Lac Operon, a case study. BioSystems, 91 (3), 438-457. | |
dc.identifier.issn | 0303-2647 | es |
dc.identifier.uri | http://hdl.handle.net/11441/68002 | |
dc.description.abstract | In this paper P systems are used as a formal framework for the specification and simulation of biological systems. In particular,
we will deal with gene regulation systems consisting of protein–protein and protein–DNA interactions that take place in different
compartments of the hierarchical structure of the living cell or in different individual cells from a colony. We will explicitly model
transcription and translation as concurrent and discrete processes using rewriting rules on multisets of objects and strings. Our
approach takes into account the discrete character of the components of the system, its random behaviour and the key role played
by membranes in processes involving signalling at the cell surface and selective uptake of substances from the environment. Our
systems will evolve according to an extension of Gillespie’s algorithm, called Multicompartmental Gillespie’s Algorithm. The well
known gene regulation system in the Lac Operon in Escherichia coli will be modelled as a case study to benchmark our approach. | es |
dc.description.sponsorship | Ministerio de Ciencia y Tecnología TIN2005-09345-C04-01 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | BioSystems, 91 (3), 438-457. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | P System | es |
dc.subject | Systems biology | es |
dc.subject | Gillespie’s Algorithm | es |
dc.subject | Gene expression control | es |
dc.subject | Lac Operon | es |
dc.title | Modelling gene expression control using P systems: The Lac Operon, a case study | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial | es |
dc.relation.projectID | TIN2005-09345-C04-01 | es |
dc.relation.publisherversion | http://www.sciencedirect.com/science/article/pii/S0303264707001128?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.biosystems.2007.02.011 | es |
dc.contributor.group | Universidad de Sevilla. TIC193: Computación Natural | es |
idus.format.extent | 20 | es |
dc.journaltitle | BioSystems | es |
dc.publication.volumen | 91 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 438 | es |
dc.publication.endPage | 457 | es |
dc.identifier.sisius | 6651884 | es |
dc.contributor.funder | Ministerio de Ciencia y Tecnología (MCYT). España | |