dc.creator | Liverani, Liliana | es |
dc.creator | Boccardi, Elena | es |
dc.creator | Beltrán, Ana M. | es |
dc.creator | Boccaccini, Aldo R. | es |
dc.date.accessioned | 2017-11-30T16:35:46Z | |
dc.date.available | 2017-11-30T16:35:46Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Liverani, L., Boccardi, E., Beltrán, A.M. y Boccaccini, A.R. (2017). Incorporation of Calcium Containing Mesoporous (MCM-41-Type) Particles in Electrospun PCL Fibers by Using Benign Solvents. Polymers, 9 (487), 1-16. | |
dc.identifier.issn | 2073-4360 | es |
dc.identifier.uri | http://hdl.handle.net/11441/67080 | |
dc.description.abstract | The electrospinning technique is a versatile method for the production of fibrous
scaffolds able to resemble the morphology of the native extra cellular matrix. In the present
paper, electrospinning is used to fabricate novel SiO2 particles (type MCM-41) containing
poly(epsilon-caprolactone) (PCL) fibers. The main aims of the present work are both the optimization
of the particle synthesis and the fabrication of composite fibers, obtained using benign solvents,
suitable as drug delivery systems and scaffolds for soft tissue engineering applications. The optimized
synthesis and characterization of calcium-containing MCM-41 particles are reported. Homogeneous
bead-free composite electrospun mats were obtained by using acetic acid and formic acid as solvents;
neat PCL electrospun mats were used as control. Initially, an optimization of the electrospinning
environmental parameters, like relative humidity, was performed. The obtained composite nanofibers
were characterized from the morphological, chemical and mechanical points of view, the acellular
bioactivity of the composite nanofibers was also investigated. Positive results were obtained in
terms of mesoporous particle incorporation in the fibers and no significant differences in terms of
average fiber diameter were detected between the neat and composite electrospun fibers. Even if
the Ca-containing MCM-41 particles are bioactive, this property is not preserved in the composite
fibers. In fact, during the bioactivity assessment, the particles were released confirming the potential
application of the composite fibers as a drug delivery system. Preliminary in vitro tests with bone
marrow stromal cells were performed to investigate cell adhesion on the fabricated composite mats,
the positive obtained results confirmed the suitability of the composite fibers as scaffolds for soft
tissue engineering | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Polymers, 9 (487), 1-16. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | electrospinning | es |
dc.subject | benign solvents | es |
dc.subject | mesoporous silica calcium containing MCM-41 | es |
dc.subject | composites | es |
dc.subject | nanofibers | es |
dc.subject | poly(epsilon-caprolactone) | es |
dc.title | Incorporation of Calcium Containing Mesoporous (MCM-41-Type) Particles in Electrospun PCL Fibers by Using Benign Solvents | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte | es |
dc.relation.publisherversion | http://dx.doi.org/doi:10.3390/polym9100487 | es |
dc.identifier.doi | doi:10.3390/polym9100487 | es |
idus.format.extent | 16 p. | es |
dc.journaltitle | Polymers | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 487 | es |
dc.publication.initialPage | 1 | es |
dc.publication.endPage | 16 | es |