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Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits

 

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dc.creator López Cortés, Luis Fernando es
dc.creator Ruiz Valderas, Rosa es
dc.creator Lucero Muñoz, María Jesús es
dc.creator Cordero, Elisa es
dc.creator Pastor Ramos, M. T. es
dc.creator Márquez, Javier es
dc.date.accessioned 2017-09-28T17:15:37Z
dc.date.available 2017-09-28T17:15:37Z
dc.date.issued 2000-03-01
dc.identifier.citation López Cortés, L.F., Ruiz Valderas, R., Lucero Muñoz, M.J., Cordero, E., Pastor Ramos, M.T. y Márquez, J. (2000). Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits. Antimicrobial Agents and Chemotherapy, 44 (3), 756-759.
dc.identifier.issn 0066-4804 (impreso) es
dc.identifier.issn 1098-6596 (electrónico) es
dc.identifier.uri http://hdl.handle.net/11441/64863
dc.description.abstract Retinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet levels were measured by high-performance liquid chromatography after administration of an intravenous dose of 120 mg/kg of body weight to 32 pigmented rabbits. A pharmacokinetic analysis was done using a two- compartment model. The penetration ratios, defined as ratios of retinal, vitreous humor, brain, and CSF areas under the concentration-time curve from 0 to 2 h were 110% ± 1%, 12.3% ± 0.7%, 118% ± 1%, and 20.2% ± 2.2%, respectively. These results suggest a good penetration of foscarnet into the retinal and brain tissues, reaching higher concentrations than those estimated from vitreous humor and CSF levels. es
dc.description.sponsorship Comisóión Interministerial de Ciencia y Tecnología SAF97-0012 es
dc.description.sponsorship Consejería de Salud Junta de Andalucía 64/96 es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher American Society for Microbiology es
dc.relation.ispartof Antimicrobial Agents and Chemotherapy, 44 (3), 756-759.
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/ *
dc.title Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits es
dc.type info:eu-repo/semantics/article es
dc.type.version info:eu-repo/semantics/publishedVersion es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Medicina es
dc.relation.projectID SAF97-0012 es
dc.relation.projectID 64/96 es
dc.relation.publisherversion http://dx.doi.org/10.1128/AAC.44.3.756-759.2000 es
dc.identifier.doi 10.1128/AAC.44.3.756-759.2000 es
idus.format.extent 4 p. es
dc.journaltitle Antimicrobial Agents and Chemotherapy es
dc.publication.volumen 44 es
dc.publication.issue 3 es
dc.publication.initialPage 756 es
dc.publication.endPage 759 es
dc.contributor.funder Comisión Interministerial de Ciencia y Tecnología (CICYT). España
dc.contributor.funder Junta de Andalucía
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