dc.creator | López Cortés, Luis Fernando | es |
dc.creator | Ruiz Valderas, Rosa | es |
dc.creator | Lucero Muñoz, María Jesús | es |
dc.creator | Cordero Matia, María Elisa | es |
dc.creator | Pastor Ramos, M. T. | es |
dc.creator | Márquez, Javier | es |
dc.date.accessioned | 2017-09-28T17:15:37Z | |
dc.date.available | 2017-09-28T17:15:37Z | |
dc.date.issued | 2000-03-01 | |
dc.identifier.citation | López Cortés, L.F., Ruiz Valderas, R., Lucero Muñoz, M.J., Cordero, E., Pastor Ramos, M.T. y Márquez, J. (2000). Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits. Antimicrobial Agents and Chemotherapy, 44 (3), 756-759. | |
dc.identifier.issn | 0066-4804 (impreso) | es |
dc.identifier.issn | 1098-6596 (electrónico) | es |
dc.identifier.uri | http://hdl.handle.net/11441/64863 | |
dc.description.abstract | Retinal, vitreous humor, brain, and cerebrospinal fluid (CSF) foscarnet levels were measured by high-performance liquid chromatography after administration of an intravenous dose of 120 mg/kg of body weight to 32 pigmented rabbits. A pharmacokinetic analysis was done using a two- compartment model. The penetration ratios, defined as ratios of retinal, vitreous humor, brain, and CSF areas under the concentration-time curve from 0 to 2 h were 110% ± 1%, 12.3% ± 0.7%, 118% ± 1%, and 20.2% ± 2.2%, respectively. These results suggest a good penetration of foscarnet into the retinal and brain tissues, reaching higher concentrations than those estimated from vitreous humor and CSF levels. | es |
dc.description.sponsorship | Comisóión Interministerial de Ciencia y Tecnología SAF97-0012 | es |
dc.description.sponsorship | Consejería de Salud Junta de Andalucía 64/96 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Society for Microbiology | es |
dc.relation.ispartof | Antimicrobial Agents and Chemotherapy, 44 (3), 756-759. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Intravitreal, retinal, and central nervous system foscarnet concentrations after rapid intravenous administration to rabbits | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | SAF97-0012 | es |
dc.relation.projectID | 64/96 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1128/AAC.44.3.756-759.2000 | es |
dc.identifier.doi | 10.1128/AAC.44.3.756-759.2000 | es |
idus.format.extent | 4 p. | es |
dc.journaltitle | Antimicrobial Agents and Chemotherapy | es |
dc.publication.volumen | 44 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 756 | es |
dc.publication.endPage | 759 | es |
dc.contributor.funder | Comisión Interministerial de Ciencia y Tecnología (CICYT). España | |
dc.contributor.funder | Junta de Andalucía | |