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Artículo
Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets
dc.creator | Díaz Moreno, Irene | es |
dc.creator | Hollingworth, David | es |
dc.creator | Kelly, Geoff | es |
dc.creator | Martin, Stephen | es |
dc.creator | García Mayoral, María Flor | es |
dc.date.accessioned | 2017-08-31T11:46:46Z | |
dc.date.available | 2017-08-31T11:46:46Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Díaz Moreno, I., Hollingworth, a., Kelly, G., Martin, S. y García Mayoral, M.F. (2010). Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets. Nucleic Acids Research, 38 (15), 5193-5205. | |
dc.identifier.issn | 1362-4962 (Electrónico) | es |
dc.identifier.issn | 0305-1048 (impreso) | es |
dc.identifier.uri | http://hdl.handle.net/11441/64106 | |
dc.description.abstract | KSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation mechanism relies on KSRP recognition of AU-rich elements in the mRNA 3′UTR, that is mediated by KSRP’s KH domains. Our structural analysis shows that the inter-domain linker orients the two central KH domains of KSRP—and their RNA-binding surfaces—creating a two-domain unit. We also show that this inter-domain arrangement is important to the interaction with KSRP’s RNA targets. | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Oxford University Press | es |
dc.relation.ispartof | Nucleic Acids Research, 38 (15), 5193-5205. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.relation.publisherversion | http://dx.doi.org/10.1093/nar/gkq216 | es |
dc.identifier.doi | 10.1093/nar/gkq216 | es |
idus.format.extent | 12 p. | es |
dc.journaltitle | Nucleic Acids Research | es |
dc.publication.volumen | 38 | es |
dc.publication.issue | 15 | es |
dc.publication.initialPage | 5193 | es |
dc.publication.endPage | 5205 | es |
Ficheros | Tamaño | Formato | Ver | Descripción |
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pub31gkq216.pdf | 18.37Mb | [PDF] | Ver/ | |