dc.creator | López Bonilla, Luis | es |
dc.creator | Carpio Rodríguez, Ana | es |
dc.creator | Prados Montaño, Antonio | es |
dc.date.accessioned | 2017-07-14T14:57:21Z | |
dc.date.available | 2017-07-14T14:57:21Z | |
dc.date.issued | 2014-10 | |
dc.identifier.citation | López Bonilla, L., Carpio Rodríguez, A. y Prados Montaño, A. (2014). Protein unfolding and refolding as transitions through virtual states. Europhysics Letters, 108 (2), 28002-p1-28002-p6. | |
dc.identifier.issn | 0295-5075 (impreso) | es |
dc.identifier.issn | 1286-4854 (electronico) | es |
dc.identifier.uri | http://hdl.handle.net/11441/62537 | |
dc.description.abstract | Single-molecule atomic force spectroscopy probes elastic properties of titin, ubiquitin and other relevant proteins. We explain bioprotein folding dynamics under both length- and force-clamp by modeling polyprotein modules as particles in a bistable potential, weakly connected by harmonic spring linkers. Multistability of equilibrium extensions provides the characteristic sawtooth force-extension curve. We show that abrupt or stepwise unfolding and refolding under force-clamp conditions involve transitions through virtual states (which are quasi-stationary domain configurations) modified by thermal noise. These predictions agree with experimental observations. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad FIS2011-28838-C02-01 FIS2011-28838-C02-02 FIS2011-24460 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | IOP Publishing Ltd. | es |
dc.relation.ispartof | Europhysics Letters, 108 (2), 28002-p1-28002-p6. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Protein unfolding and refolding as transitions through virtual states | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear | es |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/FIS2011-28838-C02-01 | es |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/FIS2011-28838-C02-02 | es |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO/FIS2011-24460 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1209/0295-5075/108/28002 | es |
dc.identifier.doi | 10.1209/0295-5075/108/28002 | es |
idus.format.extent | 6 p. | es |
dc.journaltitle | Europhysics Letters | es |
dc.publication.volumen | 108 | es |
dc.publication.issue | 2 | es |
dc.publication.initialPage | 28002-1 | es |
dc.publication.endPage | 28002-6 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | |