dc.creator | Mena, Auxiliadora | es |
dc.creator | Casa Rivas, Luis Gonzalo de La | es |
dc.date.accessioned | 2017-02-27T17:12:47Z | |
dc.date.available | 2017-02-27T17:12:47Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Mena, A. y Casa Rivas, L.G.d.L. (2013). Prepulse inhibition modulation by contextual conditioning of dopaminergic activity. Behavioural brain research, 252, 188-194. | |
dc.identifier.issn | 0166-4328 | es |
dc.identifier.uri | http://hdl.handle.net/11441/54944 | |
dc.description.abstract | When a neutral stimulus is repeatedly paired with a drug, an association is established between them
that can induce two different responses: either an opponent response that counteracts the effect of the
drug, or a response thatis similar to thatinduced by the drug. In this paper, we focus on the analysis ofthe
associations that can be established between the contextual cues and the administration of dopamine
agonists or antagonists. Our hypothesis suggests that repeated administration of drugs that modulate
dopaminergic activity in the presence of a specific context leads to the establishment of an association
that subsequently results in a conditioned response to the context that is similar to that induced by the
drug. To test this hypothesis, we conducted two experiments that revealed that contextual cues acquired
the property to modulate pre-pulse inhibition by prior pairings of such context with the dopamine antagonist
haloperidol (Experiment 1), and with the dopamine agonist d-amphetamine (Experiment 2). The
implications of these results are discussed both at a theoretical level, and attending to the possibilities
that could involve the use of context cues for the therapeutic administration of dopaminergic drugs. | es |
dc.description.sponsorship | Junta de Andalucía SEJ-02618 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación de España PSI2012-32077 | es |
dc.format | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Behavioural brain research, 252, 188-194. | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Dopamine | es |
dc.subject | Context conditioning | es |
dc.subject | Prepulse inhibition | es |
dc.title | Prepulse inhibition modulation by contextual conditioning of dopaminergic activity | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psicología Experimental | es |
dc.relation.projectID | SEJ-02618 | es |
dc.relation.projectID | PSI2012-32077 | es |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.bbr.2013.06.005 | es |
dc.identifier.doi | 10.1016/j.bbr.2013.06.005 | es |
idus.format.extent | 7 p. | es |
dc.journaltitle | Behavioural brain research | es |
dc.publication.issue | 252 | es |
dc.publication.initialPage | 188 | es |
dc.publication.endPage | 194 | es |
dc.contributor.funder | Junta de Andalucía | |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | |