Opened Access The “febrifuge principle” of cinchona barks
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Autor: Carreira, Teresa
Lopes, Sandra
Maia, Elisa
Fecha: 2007
Publicado en: 38th International Congress for the History of Pharmacy, Sevilla September 19-22 2007
Tipo de documento: Ponencia
Resumen: The antipyretic properties of cinchona barks were known since ancient times in South America, particularly in Peru. The use of these barks in medicines against “fevers” in Europe in the 17th century made the exploitation of cinchonas of Peru a highly productive process, and those cinchona trees became menaced. The Portuguese government aware of the problem searched an alternative in cinchona varieties existing in Brazil. By the beginning of 19th century, samples of different Brazilian barks were shipped to Portugal in order to evaluate their therapeutic properties, in particular their antipyretic properties. Clinical and chemical studies were carried out in Coimbra and Lisbon, by the most eminent scientists of that time, in order to find out the best way to use the barks and identify the “febrifuge principle”. During this research, Bernardino António Gomes isolated in 1810 the first known alkaloid – the cinchonine. This discovery raised international interest and led in 1820 to the ...
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