Opened Access Linking Bistable Dynamics to Metabolic P Systems
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Autor: Pagliarini, Roberto
Bianco, Luca
Manca, Vincenzo
Bessant, Conrad
Fecha: 2010
Publicado en: Proceedings of the Eighth Brainstorming Week on Membrane Computing, 205-218. Sevilla, E.T.S. de Ingeniería Informática, 1-5 de Febrero, 2010
ISBN/ISSN: 9788461423576
Tipo de documento: Ponencia
Resumen: Bistability, or more generally multistability, is an important recurring theme in biological systems. In particular, the discovery of bistability in signal pathways of genetic networks, prompts strong interest in understanding both the design and function of these networks. Therefore, modelling these systems is crucial to understand their behaviors, and also to analyze and identify characteristics that would otherwise be di cult to realize. Although di erent classes of models have been used to study bistable dynamics, there is a lag in the development of models for bistable systems starting from experimental data. This is due to the lack of detailed knowledge of biochemical reactions and kinetic rates. In this work, we propose a procedure to develop, starting from observed dynamics, Metabolic P models for multistable processes. As a case study, a mathematical model of the Schl ogel's dynamics, which represents an example of a chemical reaction system that exhibits bistabil...
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