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Notch Signalling and Cellular Fate Choices: A Short Review

Opened Access Notch Signalling and Cellular Fate Choices: A Short Review
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Autor: Henley, Beverly M.
Fecha: 2009
Publicado en: Proceedings of the Seventh Brainstorming Week on Membrane Computing, vol.I, 227-230. Sevilla, E.T.S. de Ingeniería Informática, 2-6 de Febrero, 2009
ISBN/ISSN: 9788461328369
Tipo de documento: Ponencia
Resumen: During mammalian central nervous system (CNS) development, an enormous variety of cell types are generated. This cell diversity is due in part to asymmetrical cell division. Asymmetrical segregation of Numb, a cell-determinant protein, can result in the differential activation of the Notch pathway. The Notch pathway defines one of the few fundamental signalling pathways that govern metazoan development. Notch signals link the fate decisions of one cell to those of its neighbours. Notch activation has a profound effect on many aspects of nervous system development. Here we present a brief overview of Notch signalling and reiterate some relevant questions relating to the Notch pathway.
Tamaño: 62.83Kb
Formato: PDF

URI: http://hdl.handle.net/11441/38871

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