Opened Access On Modeling Signal Transduction Networks
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Autor: Castellini, Alberto
Franco, Giuditta
Fecha: 2008
Publicado en: Proceedings of the Sixth Brainstorming Week on Membrane Computing, 67-77. Sevilla, E.T.S. de Ingeniería Informática, 4-8 de Febrero, 2008
ISBN/ISSN: 9788461244294
Tipo de documento: Ponencia
Resumen: Signal transduction networks are very complex processes employed by the living cell to suitably react to environmental stimuli. Qualitative and quantitative computational models play an increasingly important role in the representation of these networks and in the search of new insights about these phenomena. In this work we analyze some graph-based models used to discover qualitative properties of such networks. In turn, we show that MP systems can naturally extend these graph-based models by adding some qualitative elements. The case study of integrins activation during the lymphocyte recruitment, a crucial phenomenon in inflammatory processes, is described, and a first MP graph for this network is designed. Finally, we discuss some open problems related to the qualitative modeling of signaling networks.
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