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Diets Based on Virgin Olive Oil or Fish Oil but Not on Sunflower Oil Prevent Age-Related Alveolar Bone Resorption by Mitochondrial-Related Mechanism


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dc.creator Bullon, Pedro
dc.creator Battino, Maurizio
dc.creator Varela-Lopez, Alfonso
dc.creator Ramirez Tortosa, Maria Carmen
dc.creator Perez Lopez, Patricia
dc.creator Granados Principal, Sergio
dc.creator Ochoa, Julio
dc.creator Cordero, Mario D.
dc.creator Gonzalez-Alonso, Adrian
dc.creator Ramírez-Tortosa, César L.
dc.creator Corrado, Rubini
dc.creator Zizzi, Antonio
dc.creator Quiles, José L. 2016-01-08T07:08:08Z 2016-01-08T07:08:08Z 2013-09-16
dc.identifier.issn 1932-6203 es
dc.description.abstract Background/Objectives: Aging enhances frequency of chronic diseases like cardiovascular diseases or periodontitis. Here we reproduced an age-dependent model of the periodontium, a fully physiological approach to periodontal conditions, to evaluate the impact of dietary fat type on gingival tissue of young (6 months old) and old (24 months old) rats. Methods/Findings: Animals were fed life-long on diets based on monounsaturated fatty acids (MUFA) as virgin olive oil, n-6 polyunsaturated fatty acids (n-6PUFA), as sunflower oil, or n-3PUFA, as fish oil. Age-related alveolar bone loss was higher in n-6PUFA fed rats, probably as a consequence of the ablation of the cell capacity to adapt to aging. Gene expression analysis suggests that MUFA or n-3PUFA allowed mitochondria to maintain an adequate turnover through induction of biogenesis, autophagy and the antioxidant systems, and avoiding mitochondrial electron transport system alterations. Conclusions: The main finding is that the enhanced alveolar bone loss associated to age may be targeted by an appropriate dietary treatment. The mechanisms involved in this phenomenon are related with an ablation of the cell capacity to adapt to aging. Thus, MUFA or n-3PUFA might allow mitochondrial maintaining turnover through biogenesis or autophagy. They might also be able to induce the corresponding antioxidant systems to counteract age-related oxidative stress, and do not inhibit mitochondrial electron transport chain. From the nutritional and clinical point of view, it is noteworthy that the potential treatments to attenuate alveolar bone loss (a feature of periodontal disease) associated to age could be similar to some of the proposed for the prevention and treatment of cardiovascular diseases, a group of pathologies recently associated with age-related periodontitis. es
dc.format application/pdf es
dc.language.iso eng es
dc.publisher Gabriele Vincenzo Gnoni, University of Salento, Italy es
dc.relation.ispartof PloS one 8(9), e74234 es
dc.rights Attribution-NonCommercial-NoDerivatives 4.0 Internacional *
dc.rights.uri *
dc.subject Peridontitis es
dc.subject Enfermedades cardiovasculares es
dc.subject Envejecimiento es
dc.title Diets Based on Virgin Olive Oil or Fish Oil but Not on Sunflower Oil Prevent Age-Related Alveolar Bone Resorption by Mitochondrial-Related Mechanism es
dc.type info:eu-repo/semantics/article es
dc.rights.accessrights info:eu-repo/semantics/openAccess es
dc.contributor.affiliation Universidad de Sevilla. Departamento de Estomatología es
dc.relation.publisherversion 10.1371/journal.pone.0074234 es
dc.identifier.doi es
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