Opened Access Development of colonic 5-ASA beads
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Autor: Iruín Nazabal, Ana
Fernández Arévalo, María Mercedes
Álvarez Fuentes, Josefa
Holgado Villafuerte, María Ángeles
Departamento: Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica
Fecha: 2005
Publicado en: VII Congreso de la Sociedad de Farmacia Industrial y Galénica: Salamanca, 6-8 de febrero, 2005
Tipo de documento: Ponencia
Resumen: Introduction Recent studies prove that the number of patients with inflammatory bowel disease is increasing all over the world due to contamination, industrialization and changes in the style of live. Some studies have shown that 5-aminosalicylic acid (5-ASA), an anti-inflammatory agent, must be the election treatment for these pathologies. In recent years, the production of microparticles systems seems to be equally promising to develop dosage forms in order to reduce the dosage frequency (1). On the other hand, the efficacy of this drug in the treatment of inflammatory bowel diseases may be optimized with a controlled release drug delivery system which maximizes topical exposure of the drug to the diseased tissue and minimizes systemic absorption of the drug (2). Therefore, the objective of the present paper is to design an oral multi-unit dosage form containing 5-ASA that protects drug up to colon without causing toxicity. The proposed system consists of beads of several compositio...
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