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Artículo
Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer
(Impact Journals, 2017)
Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic targets for ovarian cancer. ShRNA screen performed in 42 ovarian cancer cell lines identified the ...
Artículo
BRCA1 Accelerates CtIP-Mediated DNA-End Resection
(Elsevier, 2014)
DNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslationa ...
Artículo
Nuclear poly(A)-binding protein 1 is an ATM target and essential for DNA double-strand break repair
(Oxford University Press, 2018)
The DNA damage response (DDR) is an extensive signaling network that is robustly mobilized by DNA double-strand breaks (DSBs). The primary transducer of the DSB response is the protein kinase, ataxia-telangiectasia, mutated ...
Artículo
Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination
(Oxford University Press, 2013)
While regulating the choice between homologous recombination and non-homologous end joining (NHEJ) as mechanisms of double-strand break (DSB) repair is exerted at several steps, the key step is DNA end resection, which in ...
Artículo