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Artículo
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent ...
Artículo
The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
(Public Library of Science, 2017)
RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence of RNase H enzymes, RNA-DNA hybrids accumulate, resulting in replication stress, DNA damage and ...
Artículo
SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination
(Elsevier, 2016)
Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, but at the same time HR can lead to loss of heterozygosity and uncontrolled recombination can be ...
Artículo
Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
(Cold Spring Harbor Laboratory Press, 2016)
Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a ...