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Artículo
Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?
(Public Library of Science, 2015)
Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular (CCC) DNA, which serves as the transcriptional template for all viral RNAs. CCC DNA is converted from ...
Artículo
Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks
(Elsevier, 2015)
DNA double-strand breaks (DSBs) elicit the so-called DNA damage response (DDR), largely relying on ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PKcs), two members of the PI3K-like kinase family, ...