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Mostrando ítems 1-7 de 7
Artículo
Non-recombinogenic roles for Rad52 in translesion synthesis during DNA damage tolerance
(Wiley-Blackwell, 2021)
DNA damage tolerance relies on homologous recombination (HR) and translesion synthesis (TLS) mechanisms to fill in the ssDNA gaps generated during passing of the replication fork over DNA lesions in the template. Whereas ...
Artículo
SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination
(Elsevier, 2016)
Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, but at the same time HR can lead to loss of heterozygosity and uncontrolled recombination can be ...
Artículo
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
(Shared Science Publishers OG, 2019)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular ...
Artículo
Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
(Cold Spring Harbor Laboratory Press, 2016)
Mph1 is a member of the conserved FANCM family of DNA motor proteins that play key roles in genome maintenance processes underlying Fanconi anemia, a cancer predisposition syndrome in humans. Here, we identify Mte1 as a ...
Artículo
BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote continuous DNA synthesis
(Nature Research, 2024-05-20)
Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway and, together with BARD1, forms a heterodimer ...
Artículo
Regulation of replication fork advance and stability by nucleosome assembly
(Multidisciplinary Digital Publishing Institute (MDPI), 2017)
he advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead of the fork and the rapid assembly of parental and de novo histones at the newly synthesized strands ...
Artículo
PLK1 Regulates CtIP and DNA2 Interplay in Long-range DNA end Resection.
(Cold Spring Harbor Laboratory Press, 2023)
DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-range resection to stimulate MRE11–RAD50–NBS1 (MRN) to endonucleolytically cleave 5′-terminatedDNAto bypass protein blocks. CtIP ...