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Mostrando ítems 1-9 de 9
Artículo
The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)
Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication ...
Artículo
Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
(Elsevier, 2022)
DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads to DNA damage and genomic instability. Replication stress is commonly associated with slow and stalled ...
Artículo
Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
(2018)
R loops are nucleic acid structures comprising an DNA-RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent ...
Artículo
Actin nucleators safeguard replication forks by limiting nascent strand degradation
(Oxford University Press, 2023)
Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability of cells to respond to replicative stress (RS) and protect replication forks. These responses rely ...
Artículo
ATRX-Deficient High-Grade Glioma Cells Exhibit Increased Sensitivity to RTK and PDGFR Inhibitors
(MDPI, 2022)
High-grade glioma, including anaplastic astrocytoma and glioblastoma (GBM) patients, have a poor prognosis due to the lack of effective treatments. Therefore, the development of new therapeutic strategies to treat these ...
Artículo
DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
(Elsevier, 2023)
Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches and cellular analysis of specific mutants have uncovered factors potentially involved in R-loop ...
Artículo
WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage.
(Nature Research, 2022)
Perturbation in the replication-stress response (RSR) and DNA-damage response (DDR) causes genomic instability. Genomic instability occurs in Wiskott-Aldrich syndrome (WAS), a primary immunodeficiency disorder, yet the ...
Artículo
Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability
(Springer Nature, 2024-05-26)
RECQL5 is a member of the conserved RecQ family of DNA helicases involved in the maintenance of genome stability that is specifically found in higher eukaryotes and associates with the elongating RNA polymerase II. To ...
Artículo
PLK1 Regulates CtIP and DNA2 Interplay in Long-range DNA end Resection.
(Cold Spring Harbor Laboratory Press, 2023)
DNA double-strand break (DSB) repair is initiated by DNA end resection. CtIP acts in short-range resection to stimulate MRE11–RAD50–NBS1 (MRN) to endonucleolytically cleave 5′-terminatedDNAto bypass protein blocks. CtIP ...