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- Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)
- Listar Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) por autor
Listar Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) por autor "Caldecott, Keith W."
Mostrando ítems 1-4 de 4
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Artículo
Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?
Cui, Xiuji; McAllister, Rebecca; Boregowda, Rajeev; Sohn, Ji A.; Cortés Ledesma, Felipe; Caldecott, Keith W.; Seeger, Christoph; Hu, Jianming (Public Library of Science, 2015)Hepatitis B virus (HBV) replication and persistence are sustained by a nuclear episome, the covalently closed circular ...
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TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
Gómez Herreros, Fernando; Zagnoli Vieira, Guido; Ntai, Ioanna; Martínez Macías, María Isabel; Anderson, Rhona M.; Herrero Ruíz, Andrés; Caldecott, Keith W. (Nature Publishing Group, 2017)DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome ...
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TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo
Gómez Herreros, Fernando; Romero Granados, Rocío; Zeng, Zhihong; Álvarez Quilón, Alejandro; Quintero Ruiz, María Cristina; Ju, Limei; Umans, Lieve; Vemeire, Liesbeth; Huylebroeck, Danny; Caldecott, Keith W.; Cortés Ledesma, Felipe (Public Library of Science, 2013)Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate ...
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Artículo
TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
Zeng, Zhihong; Cortés Ledesma, Felipe; El Khamisy, Sherif F.; Caldecott, Keith W. (American Society for Biochemistry and Molecular Biology, 2011)Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand ...