Listar Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) por título
Mostrando ítems 142-161 de 187
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Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer
(Impact Journals, 2017)Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic ...
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TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
(Nature Publishing Group, 2017)DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome ...
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TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands
(Wiley-Blackwell, 2020)Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating ...
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TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo
(Public Library of Science, 2013)Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate ...
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TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
(American Society for Biochemistry and Molecular Biology, 2011)Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand ...
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The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
(American Association for Cancer Research, 2019)R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
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The cannabinoid ligand LH-21 reduces anxiety and improves glucose handling in diet-induced obese pre-diabetic mice
(Nature Publishing Group, 2017)LH-21 is a triazol derivative that has been described as a low-permeant neutral CB1 antagonist, though its pharmacology ...
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The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction
(Nature Publishing Group, 2017)The eukaryotic chaperonin CCT (chaperonin containing TCP-1) uses cavities built into its double-ring structure to encapsulate ...
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The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
(Nature Research, 2023)Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large ...
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The Cornelia de Lange Syndrome-associated factor NIPBL interacts with BRD4 ET domain for transcription control of a common set of genes
(Springer Nature, 2019-07-18)Mutations in NIPBL are the major cause of Cornelia de Lange Syndrome (CdLS). NIPBL is the cohesin-loading factor and has ...
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The diabetes-linked transcription factor PAX4: from gene to functional consequences
(MDPI, 2017)Paired box 4 (PAX4) is a key factor in the generation of insulin producing β-cells during embryonic development. In adult ...
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The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
(EMBO Press, 2019-07-24)Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...
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The need to regulate replication fork speed
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The Nup84 complex coordinates the DNA damage response to warrant genome integrity
(Oxford University Press, 2019)DNA lesions interfere with cellular processes such as transcription and replication and need to be adequately resolved to ...
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The PTGS2/COX2-PGE2 Signaling Cascade in Inflammation: Pro or Anti? A Case Study with Type 1 Diabetes Mellitus
(Ivyspring International Publisher, 2023)Prostaglandins are lipid mediators involved in physiological processes, such as constriction or dilation of blood vessels, ...
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The Rad50 coiled-coil domain is indispensable for Mre11 complex functions
(Nature Publishing Group, 2011)The Mre11 complex (Mre11, Rad50 and Xrs2 in Saccharomyces cerevisiae) influences diverse functions in the DNA damage ...
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The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores
(Elsevier, 2011)Transcription hinders replication fork progression and stability, and the Mec1/ATR checkpoint protects fork integrity. ...
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The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage
(Public Library of Science, 2017)RNA-DNA hybrids are naturally occurring obstacles that must be overcome by the DNA replication machinery. In the absence ...
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The THO Complex as a Paradigm for the Prevention of Cotranscriptional R-Loops
(Cold Spring Harbor Laboratory Press, 2019)Different proteins associate with the nascent RNA and the RNA polymerase (RNAP) to catalyze the transcription cycle and ...