Listar Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER) por título
Mostrando ítems 127-146 de 186
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R Loops: From Physiologicalto Pathological Roles
(Elsevier, 2019-10-17)DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent non-scheduled co-transcriptional ...
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Rat1p maintains RNA polymerase II CTD phosphorylation balance
(Cold Spring Harbor Laboratory Press, 2014)In S. cerevisiae, the 5′-3′ exonuclease Rat1p partakes in transcription termination. Although Rat1p-mediated RNA degradation ...
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Regulation of replication fork advance and stability by nucleosome assembly
(Multidisciplinary Digital Publishing Institute (MDPI), 2017)he advance of replication forks to duplicate chromosomes in dividing cells requires the disassembly of nucleosomes ahead ...
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Resveratrol Ameliorates the Maturation Process of β-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells
(Public Library of Science, 2015)Human embryonic stem cells (hESCs) retain the extraordinary capacity to differentiate into different cell types of an adult ...
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Retinal pigment epithelium degeneration caused by aggregation of PRPF31 and the role of HSP70 family of proteins
(BMC (part of Springer Nature), 2020)Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism ...
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Roles of Extracellular Vesicles Associated Non-coding RNAs in Diabetes Mellitus
(Frontiers Media SA, 2022)Extracellular vesicles (EVs), especially exosomes (50 to 150 nm), have been shown to play important roles in a wide range ...
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Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion
(Nature Research, 2019)Genome stability involves accurate replication and DNA repair. Broken replication forks, such as those encountering a nick, ...
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Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos
(Oxford University Press, 2023-03-29)Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of ...
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Spontaneous deamination of cytosine to uracil is biased to the non-transcribed DNA strand in yeast
(Elsevier, 2023-06)Transcription in Saccharomyces cerevisiae is associated with elevated mutation and this partially reflects enhanced damage ...
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Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
(Taylor & Francis, 2020)A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
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Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy
(Nature Research, 2024-01-17)ATTR amyloidosis is caused by the deposition of transthyretin in the form of amyloid fibrils in virtually every organ of ...
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SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination
(Elsevier, 2016)Homologous recombination (HR) is essential for maintenance of genome stability through double-strand break (DSB) repair, ...
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Sumoylation of Smc5 Promotes Error-free Bypass at Damaged Replication Forks
(Elsevier (Cell Press): OAJ, 2019)Replication of a damaged DNA template can threaten the integrity of the genome, requiring the use of various mechanisms ...
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Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer
(Impact Journals, 2017)Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic ...
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TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
(Nature Publishing Group, 2017)DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome ...
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TDP2 suppresses genomic instability induced by androgens in the epithelial cells of prostate glands
(Wiley-Blackwell, 2020)Androgens stimulate the proliferation of epithelial cells in the prostate by activating topoisomerase 2 (TOP2) and regulating ...
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TDP2-Dependent Non-Homologous End-Joining Protects against Topoisomerase II-Induced DNA Breaks and Genome Instability in Cells and In Vivo
(Public Library of Science, 2013)Anticancer topoisomerase >poisons> exploit the break-and-rejoining mechanism of topoisomerase II (TOP2) to generate ...
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TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage
(American Society for Biochemistry and Molecular Biology, 2011)Topoisomerase II (Top2) activity involves an intermediate in which the topoisomerase is covalently bound to a DNA double-strand ...
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The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
(American Association for Cancer Research, 2019)R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...